This study looked at a specific group of women with a type of breast cancer called ductal carcinoma in situ (DCIS) that is positive for estrogen receptors (ER+). They were treated with a drug called letrozole for 6 months before surgery. The main goal was to see how well the treatment worked by looking at changes in MRI scans before and after treatment.
Researchers took samples of tissue from patients before and after treatment. They looked for changes in the cancer cells using special tests. They also checked the levels of certain genes to see how they changed with treatment. The response to the treatment was measured by looking at specific markers in the tissue samples.
Out of 29 patients, 5 had a complete response to the treatment, meaning their cancer showed no signs after treatment. The study found that the type of cancer (luminal A) responded better to the treatment. However, some patients did not respond well, and their cancer types were different. The treatment also changed some cancer characteristics in certain patients.
Understanding how different types of breast cancer respond to treatment can help doctors choose better treatment plans. This study provides valuable information for improving breast cancer care and may lead to better outcomes for patients.
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