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APPROACH: Analysis of Proton versus Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health — study protocol paper for a phase III multicentre, open-label randomised controlled trial

Introduction

Oligodendroglioma (ODG) is a rare brain tumor that mostly affects younger adults. Treatment usually involves surgery, radiation therapy (RT), and chemotherapy. However, traditional RT can lead to long-term problems with thinking and quality of life. Proton beam therapy (PBT) may offer a better option by reducing radiation exposure to healthy brain tissue.

Study Overview

The APPROACH study is a large trial comparing PBT and traditional photon RT for treating ODG. It includes 246 participants from various UK centers. Patients will receive either PBT or photon RT, followed by chemotherapy. The study will evaluate the effectiveness of PBT in preserving cognitive function over five years.

Measurable Outcomes

The trial will look at:

  • Cognitive function
  • Side effects of treatment
  • Quality of life
  • How well the tumor responds to treatment
  • Survival rates

Goals for Clinics and Patients

The study aims to provide clear results that will help healthcare providers choose the best treatment options for ODG patients, improving their long-term health and quality of life.

Selecting AI Tools

Clinics can enhance their treatment processes by selecting AI tools that meet their specific needs. These tools can help track patient outcomes and improve treatment plans.

Implementation Steps

Start with a pilot project to test AI solutions alongside the APPROACH study findings. Monitor the results and make adjustments as needed to maximize impact in real-world settings.

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