A randomized controlled trial to assess if changing sleep timing can improve glucose metabolism in people with prediabetes and type 2 diabetes

Practical solutions and value

Social jetlag, a disruption in sleep timing, is linked to glucose metabolism issues, insulin resistance, and metabolic syndrome risks. This study aims to determine if a 3-week intervention involving morning bright light therapy, evening light reduction, and sleep advance instructions can reduce social jetlag and improve glycemic and metabolic control, sleep, mood, and quality of life in individuals with prediabetes and type 2 diabetes.

Intervention Details

The intervention involves 60 participants with prediabetes or type 2 diabetes and >1 hour of social jetlag. They will receive morning bright light therapy and wear bright light-dimming goggles in the evenings for 3 weeks. The control group will maintain their regular sleep habits.

Outcome Measures

The primary outcome is glycated hemoglobin (HbA1c) after 12 weeks. Secondary outcomes include social jetlag, insulin sensitivity, metabolic outcomes, mood, and quality of life. Additional factors such as nervous system activity, sleep quality, melatonin onset, satiety, diet, and physical activity will also be measured to assess their impact.

Value Proposition

This intervention aims to reduce social jetlag and in turn improve glycemic and metabolic control in individuals with type 2 diabetes. By achieving this, the study seeks to positively impact population health and reduce the disease burden of type 2 diabetes.