A Randomized Trial on Pharmacogenomics for Chronic Pain Treatment
Study Overview
This trial explored the impact of pharmacogenomic (PGx) results on patients with chronic pain in primary care, comparing it to standard treatment methods. It was a largely virtual study where participants were divided into two groups: one receiving PGx care and the other receiving standard care.
Participants and Method
Adults experiencing pain for at least three months and treated with tramadol, codeine, or hydrocodone took part in the trial. Alternative pain medications were suggested for patients identified as CYP2D6 intermediate or poor metabolizers. A total of 253 participants were included in the study.
Key Findings
The analysis focused on changes in pain intensity over three months. Results showed:
- No significant difference in pain intensity between the PGx group and the standard care group (-0.10 vs. -0.21; p = 0.74).
- 69% of PGx participants received care aligned with their genetic results compared to 63% in standard care.
- In patients with poor metabolism, those receiving PGx-aligned care showed a slight improvement in pain intensity compared to those who did not align (change of -0.21 vs. -0.06).
Conclusion
The trial indicates that using PGx information did not significantly change prescribing practices or overall clinical outcomes. However, there was a slight improvement in pain intensity for those whose treatment aligned with PGx recommendations. Future research should focus on effective ways to implement PGx in clinical settings.
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