A three-gene expression score for predicting clinical benefit to anti-PD-1 blockade in advanced renal cell carcinoma

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Study Summary

In a recent study, researchers aimed to develop a gene expression score to predict the clinical benefit of the anti-PD-1 antibody nivolumab in patients with advanced clear cell renal cell carcinoma (RCC). The study integrated data from the CheckMate-009, CheckMate-010, and CheckMate-025 clinical trials.

Key Findings

  • A three-gene expression score (3GES) was developed, incorporating HMGA1, NUP62, and ARHGAP42 transcripts, which showed prognostic value for overall survival in patients treated with nivolumab.
  • The predictive value of the 3GES for nivolumab was confirmed in a separate group of patients from the CheckMate-025 phase 3 clinical trial.
  • The study also explored the correlation of the 3GES with various clinical, molecular, and immune tumor characteristics.

Practical Implications

If further validated in additional studies, the 3GES could serve as a valuable tool for guiding the design of immune checkpoint blockade-based clinical trials for advanced clear cell RCC in the future.

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