New Insights from the Second Revision of the International Staging System
Overview of the Study
The International Staging System for multiple myeloma has been updated to include new factors that affect patient prognosis. This update, called R2-ISS, enhances our understanding of multiple myeloma by considering additional high-risk features.
Study Findings
In the ICARIA-MM and IKEMA studies, which involved 609 patients, the following classifications were made:
- Stage I: 68 patients (11.2%)
- Stage II: 136 patients (22.3%)
- Stage III: 204 patients (33.5%)
- Stage IV: 55 patients (9.0%)
- Not classified: 146 patients (24.0%)
Patients classified as R2-ISS stage II or higher had shorter progression-free survival rates compared to those classified as stage I, highlighting the importance of accurate staging.
Impact of Treatment
Adding isatuximab to treatment regimens significantly improved progression-free survival across all R2-ISS stages. This suggests that the R2-ISS can effectively guide treatment decisions in patients with relapsed/refractory multiple myeloma.
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