Bone Pain and Survival Among Patients With Metastatic, Hormone-Sensitive Prostate Cancer: A Secondary Analysis of the SWOG-1216 Trial
Summary:
The study aimed to compare survival outcomes among patients with metastatic, hormone-sensitive prostate cancer (MHSPC) based on the presence or absence of baseline bone pain at diagnosis.
Methodology:
The analysis used patient-level data from the SWOG-1216 trial, a phase 3, prospective randomized clinical trial. It included patients with newly diagnosed MHSPC from 248 academic and community centers across the US. The study involved patients who received androgen deprivation therapy (ADT) with orteronel or ADT with bicalutamide.
Findings:
Of the 1279 male study participants, 301 had baseline bone pain at diagnosis, while 896 did not. Patients with bone pain were found to have worse survival outcomes compared to those without bone pain. The data suggests that prioritizing these patients for enrollment in clinical trials and including bone pain in prognostic models of MHSPC may be beneficial.
Value and Practical Solutions:
The study’s findings can aid in patient counseling and prioritizing patients for clinical trials. It highlights the importance of considering bone pain in prognostic models of MHSPC. This information can be valuable for clinicians in guiding patient care and treatment decisions.
Trial Registration:
ClinicalTrials.gov Identifier: NCT01809691
Impact on Clinical Practice:
Clinical trials play a crucial role in developing effective treatments. The study’s results can potentially influence the inclusion of bone pain in prognostic models and patient prioritization for clinical trials. This can ultimately improve patient outcomes in MHSPC.
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