Brain Radiotherapy with Camrelizumab and Platinum-Doublet Chemotherapy for NSCLC
Study Overview
This study examines the effectiveness and safety of combining brain radiotherapy with camrelizumab and chemotherapy for patients with advanced non-small-cell lung cancer (NSCLC) that has spread to the brain.
Key Points
- Background: Patients with NSCLC and brain metastases often face limited treatment options and poor outcomes.
- Trial Structure: This was a phase 2 trial conducted in nine hospitals in China, including 65 patients aged 18 and older with advanced NSCLC and brain metastases.
- Treatment Protocol: Patients received either stereotactic radiosurgery or whole-brain radiotherapy along with camrelizumab and platinum-doublet chemotherapy for four to six cycles.
- Primary Outcome: The main goal was to measure the 6-month progression-free survival rate.
Results
- Out of 67 patients assessed, 65 were treated. The average age was 66 years.
- The 6-month progression-free survival rate was 71.7%.
- Common side effects included low blood cell counts, but there were no treatment-related deaths.
Conclusion
This treatment combination shows promise for patients with brain metastases from NSCLC. More research through randomized controlled trials is needed to confirm these results.
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