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Practical Solutions and Value of Cancer Nutritional-Immunotherapy
The study explores the use of carbonyl iron powder (CIP), an FDA-approved iron supplement, in anti-cancer treatment. This material is repurposed for its potential as a catalyst in the Fenton reaction, activator for dihydroartemisinin (DHA), and as a potent agent for NIR-II photothermal therapy (PTT) in an injectable alginate hydrogel form.
Key Findings
- CIP-ALG gel causes rapid temperature rise in the tumor site under NIR-II laser irradiation, leading to complete tumor ablation.
- Photothermal-ablation results in significant release of ATP, leading to primary tumor ablation and inhibition of secondary tumor simultaneously under the nutritional-photothermal therapy (NT/PTT) approach.
This pioneering trial confirms the concept of material repurposing and introduces CIP-ALG-mediated NT/PTT/immunotherapy as a safe and efficient option for tumor therapy.
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