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Case Report: Long-Term Survival of a Patient with Cerebral Metastasized Ovarian Carcinoma Treated with a Personalized Peptide Vaccine and Anti-PD-1 Therapy

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Case Report: Long-Term Survival of a Patient with Cerebral Metastasized Ovarian Carcinoma

Treatment with Personalized Peptide Vaccine and Anti-PD-1 Therapy

  • Ovarian cancer is a common and deadly cancer among women, especially in advanced stages.
  • A 49-year-old patient with stage III ovarian cancer received a personalized peptide vaccine and anti-PD-1 therapy after standard treatments failed.
  • The vaccine targeted specific mutations in the tumor and was administered over 50 months.
  • Anti-PD-1 therapy was given to prevent further disease progression.
  • Tests showed strong immune responses and T-cell activation against the vaccinated peptides.
  • Genetic and immunohistochemical analysis revealed a potential tumor escape mechanism.
  • The study suggests that personalized peptide vaccines could be beneficial for cancer stages with limited treatment options.
  • Further investigation into the loss of Beta-2 microglobulin as a tumor escape mechanism is recommended in clinical trials using anti-cancer vaccines and immune-checkpoint inhibitors.

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Full research Case Report: Long-Term Survival of a Patient with Cerebral Metastasized Ovarian Carcinoma Treated with a Personalized Peptide Vaccine and Anti-PD-1 Therapy: https://pubmed.ncbi.nlm.nih.gov/38675779/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1B1L42DK3a-JWCV4P_PtHHBmWjwBLFNcDXsYJkbqjQD0Ca7UQh&fc=None&ff=20240427133354&v=2.18.0.post9+e462414

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