Clinical trials

“`html Improved Diagnosis and Treatment for Myelodysplastic Neoplasms (MDS) with Ring Sideroblasts or SF3B1 Mutations Study Overview Reviewed 395 MDS patients at our center from 2018 to 2023 Identified 39 patients with lower-risk MDS and SF3B1 mutations Supports the revised 2022 definitions of the World Health Organization (WHO) and International Consensus Classification (ICC) Key Findings […] ➡️➡️➡️

“`html Physiological Variability during Prehospital Stroke Care: Which Monitoring and Interventions Are Used? Healthcare (Basel). 2024 Apr 15;12(8):835 ABSTRACT Prehospital care for stroke is crucial for quick diagnosis and management. This review looks at how monitoring and interventions for physiological parameters in stroke patients can be improved to enhance outcomes. The review included 19 studies […] ➡️➡️➡️

“`html Effectiveness of Non-Pharmacological Interventions for Dementia among the Elderly: A Randomized Controlled Trial Summary No medicine can cure dementia, but non-pharmacological treatments can help slow down the disease and reduce symptoms. Pharmacological treatments have side effects and are expensive, making non-pharmacological interventions more urgent. This study evaluated the effectiveness of non-pharmacological interventions in dementia […] ➡️➡️➡️

The Flow-S Device: A Practical Solution for Field-Based Diagnosis of Schistosoma Infection Background: – A new device called Flow-S has been developed to simplify the diagnosis of active Schistosoma infection in the field using urine samples. – Current laboratory-based tests for this infection require complex pre-treatment steps that are not suitable for field use. Key […] ➡️➡️➡️

“`html Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure Practical Solutions and Value Heart failure is a major global health issue with high hospitalization rates and mortality. There is a need for new and reliable biomarkers for diagnosing, predicting outcomes, and guiding treatment for patients with acute heart failure. Recent research […] ➡️➡️➡️

“`html Development and Characterisation of a New Patient-Derived Xenograft Model of AR-Negative Metastatic Castration-Resistant Prostate Cancer Key Points: Prostate cancer is evolving, leading to more treatment-induced neuroendocrine and double-negative prostate cancer cases. These subtypes are resistant to standard treatments, making it challenging to find effective therapies. The CU-PC01 PDX model represents AR-negative mCRPC with specific […] ➡️➡️➡️

“`html Primary Arterial Hypertension and Cognitive Function in Young Adults Key Findings: Young adults with primary hypertension (PH) showed poorer performance in tasks of response speed and sustained attention compared to healthy controls. High office systolic blood pressure (oSBP) was independently associated with poor sustained attention. Practical Solutions and Value: Regular monitoring and management of […] ➡️➡️➡️

Concomitant and Bismuth Quadruple Therapy for Helicobacter pylori Eradication in Southern Italy Preliminary Data from a Randomized Clinical Trial Antibiotics (Basel). 2024 Apr 10;13(4):348. doi: 10.3390/antibiotics13040348. ABSTRACT Concomitant therapy (CT) and bismuth quadruple therapy (BQT) are recommended in areas with high clarithromycin resistance for Helicobacter pylori (H. pylori) eradication. We compared CT and BQT as […] ➡️➡️➡️

“`html Enhancing Yield and Improving Grain Quality in Japonica Rice Practical Solutions and Value Adapting Japonica rice varieties from the northeast to lower latitudes Using CRISPR-Cas9 technology to edit the EHD1 gene in premium Japonica cultivars Field trials demonstrating increased yield and retention of desirable traits in new ehd1 mutants Disabling Ehd1 to postpone flowering, […] ➡️➡️➡️

Association between Gene Mutations and Progesterone Resistance in Endometriosis Practical Solutions and Value: Endometriosis, a condition causing severe pain, is linked to cancer-related gene mutations like KRAS and PIK3CA. Study focused on the impact of these mutations on progesterone resistance in endometriotic cell lines. Transduction of progesterone receptor (PR-B) to mutated cell lines revealed progesterone […] ➡️➡️➡️

“`html Phase II Study Summary A clinical trial was conducted to evaluate the effectiveness and safety of using a specific chemotherapy and radiotherapy regimen followed by surgery in treating advanced esophageal cancer. Practical Solutions and Value The study enrolled 24 newly diagnosed esophageal cancer patients to assess the treatment approach. The treatment involved a specific […] ➡️➡️➡️

“`html Immunohistochemistry of Lung Cancer Biomarkers Practical Solutions and Value Immunohistochemical (IHC) staining is a cost-effective testing method for pulmonary biomarker testing. Specific antibody clones for certain genetic alterations, such as anaplastic lymphoma kinase, ROS-1, and neurotrophic tropmyosin receptor kinase, have provided robust results for targeted therapy. IHC can be used as a primary testing […] ➡️➡️➡️

“`html Diagnostic Positron Emission Tomography Imaging with Zirconium-89 Desferrioxamine B Squaramide: From Bench to Bedside Overview Molecular imaging with radiolabeled antibodies and Positron Emission Tomography (PET) can provide valuable information about specific biological interactions in individual patients. This approach has potential applications in identifying patients for targeted therapies, characterizing diseases, and monitoring treatment response. Using […] ➡️➡️➡️

“`html Practical Solutions and Value of Cancer Nutritional-Immunotherapy The study explores the use of carbonyl iron powder (CIP), an FDA-approved iron supplement, in anti-cancer treatment. This material is repurposed for its potential as a catalyst in the Fenton reaction, activator for dihydroartemisinin (DHA), and as a potent agent for NIR-II photothermal therapy (PTT) in an […] ➡️➡️➡️

“`html Summary of Clinical Trial: Bystander interaction with a novel multipurpose medical drone: A simulation trial Introduction Medical drones are new technology that can help in emergencies. Lay rescuers use these drones, but we don’t know much about how people interact with them and the best way to design them. Methods 24 simulations of adult […] ➡️➡️➡️

“`html Clinical Trial: Complications following surgical treatment of ankle fractures in the elderly: can they be avoided? Key Findings: Geriatric patients (65 years and older) have higher complication rates following surgical treatment of ankle fractures. Commonly used diagnostic and treatment methods do not account for the specific needs of elderly patients, increasing the risk of […] ➡️➡️➡️

“`html Practical Solutions and Value in Clinical Trial Case Study: Multiple Brain Tuberculomas in the Subarachnoid Cisterns Recognition of Radiological Characteristics Development of Paradoxical Response during Antituberculosis Treatment Brain tuberculoma within subarachnoid cisterns is rare in Japan, making diagnosis challenging. A 70-year-old woman with suspected tuberculous meningitis (TBM) was enrolled in a clinical trial for […] ➡️➡️➡️

“`html COVID-19 Surveillance Using Consumer Wearable Devices Summary Consumer wearable devices like wristbands and smartwatches can help monitor COVID-19 patients. A study was conducted to see how well wearable devices can track COVID-19 patients of different severity. Physiological data and electronic questionnaires were collected from the devices worn by patients until 14 days after they […] ➡️➡️➡️

“`html Automated Osteoporosis Classification and T-Score Prediction Practical Solutions and Value Using a deep learning algorithm, this study aims to classify osteoporosis and predict T-scores on the hip region through simple hip radiographs. A dataset of 3460 hip images from 1730 patients was used to train and test the proposed model, which showed a better […] ➡️➡️➡️

“`html Effects of Korean Versus Western Diets on Reproductive Function in Young Korean Men: A 12-Week Randomized Parallel Clinical Trial ABSTRACT Unhealthy diets may lead to a decline in sperm quality. This study compared the effects of Korean and Western diets on reproductive function in young Korean men. METHODS Participants were given either the Korean […] ➡️➡️➡️