Molecular Detection of SARS-CoV-2 From Throat Swabs: Practical Solutions and Value
Background
Testing for SARS-CoV-2 is crucial for early COVID-19 treatment and controlling the spread of infection. Proper upper respiratory specimen collection is vital for accurate diagnosis. Throat swabs are commonly used for mass testing, but their sensitivity for SARS-CoV-2 diagnosis varies.
Objective
This study aims to compare the sensitivity and patient discomfort of throat swabs including palatine tonsil specimens versus swabs from the posterior oropharyngeal wall only for SARS-CoV-2 testing.
Methods
We will conduct a randomized controlled study to compare the molecular detection rate of SARS-CoV-2 using throat swabs from the posterior oropharyngeal wall and palatine tonsils versus swabs from the posterior oropharyngeal wall only. Participants will be randomized in a 1:1 ratio.
Results
A total of 2315 participants were enrolled in this study between November 10, 2022, and December 22, 2022. Results from the follow-up questionnaire are expected to be completed at the beginning of 2024.
Conclusions
This clinical trial will provide information on whether including palatine tonsil specimens in throat swabs improves the diagnostic sensitivity for SARS-CoV-2 molecular detection, potentially influencing future testing recommendations and providing insights into SARS-CoV-2 tissue tropism.
Trial Registration
ClinicalTrials.gov NCT05611203; ClinicalTrials.gov/study/NCT05611203
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