Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAbbreviated or Standard Antiplatelet Therapy After PCI in Diabetic Patients at High Bleeding Risk
Abbreviated or Standard Antiplatelet Therapy After PCI in Diabetic Patients at High Bleeding Risk Study Overview This study examines the effects of abbreviated antiplatelet therapy (APT) compared to standard APT in patients with high bleeding risk (HBR) who have diabetes mellitus (DM). The goal is to find out if a shorter treatment duration can reduce […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAvatar Intervention in Virtual Reality for Cannabis Use Disorder in Individuals With Severe Mental Disorders: Results From a 1-Year, Single-Arm Clinical Trial
Avatar Intervention in Virtual Reality for Cannabis Use Disorder Study Overview This study explored a new way to treat cannabis use disorder (CUD) in individuals with severe mental disorders (SMD) using virtual reality (VR). The goal was to see if this method could help reduce cannabis use and improve overall well-being over a year. Why […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of community health education on mothers’ knowledge of obstetric danger signs and birth preparedness and complication readiness practices in southern Ethiopia: A cluster randomized controlled trial
Effect of Community Health Education on Mothers in Southern Ethiopia Introduction Increasing mothers’ understanding of obstetric danger signs (ODS) and promoting birth preparedness and complication readiness (BPCR) are vital for improving maternal health services in low-income countries. Health education interventions (HEI) led by women’s groups could be an effective way to achieve this. However, there […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA Blended Learning Course on the Diagnostics of Mental Disorders: Multicenter Cluster Randomized Noninferiority Trial
A Blended Learning Course on the Diagnostics of Mental Disorders Overview This study focused on improving how mental disorders are diagnosed through a blended learning course. Accurate diagnoses are crucial for effective patient treatment, and poor diagnoses can lead to serious issues. Study Goals The aim was to develop and assess a blended learning course […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMinimal changes in sleep parameters during overnight ambulatory blood pressure monitoring do not affect outcomes
Minimal Changes in Sleep During Overnight Blood Pressure Monitoring Study Overview This study investigated how overnight ambulatory blood pressure monitoring (ABPM) affects sleep. While ABPM is the best method for checking blood pressure, it might disrupt sleep. Previous research showed mixed results, and this study is unique because it used polysomnography, a more precise sleep […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Population pharmacokinetic analysis of quizartinib in patients with newly diagnosed FLT3-internal-tandem-duplication-positive acute myeloid leukemia
Population Pharmacokinetic Analysis of Quizartinib in AML Patients Study Overview This study focuses on the pharmacokinetics (PK) of quizartinib and its active metabolite, AC886, in patients with newly diagnosed FLT3-internal-tandem-duplication-positive acute myeloid leukemia (AML). The analysis used data from the Phase 3 QuANTUM-First trial and 12 earlier studies. Key Findings Three-Compartment Model: Quizartinib PK was […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDirect and Gradual Electrical Testicular Shocks Stimulate Spermatogenesis and Activate Sperms in Infertile Men: A Randomized Controlled Trial
Direct and Gradual Electrical Testicular Shocks Improve Sperm Production in Infertile Men Study Overview About 15% of couples face infertility, with male factors contributing to nearly half of the cases. This often results from issues like low sperm production and sperm dysfunction. In this study, 90 infertile men with various sperm issues participated in a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTransbronchial Needle Aspiration via Ultrathin Bronchoscope Improves Diagnostic Yield for Peripheral Lung Lesions: Randomized Sequencing Trial
Transbronchial Needle Aspiration via Ultrathin Bronchoscope Improves Diagnostic Yield for Peripheral Lung Lesions Study Overview This study investigates how combining ultrathin bronchoscopy with peripheral transbronchial needle aspiration (pTBNA) can enhance the diagnosis of peripheral pulmonary lesions (PPLs). Key Findings Improved Diagnostic Yield: The overall diagnostic yield was 66.3%, with pTBNA contributing an additional 11.9% of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial
The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on Women with Breast Cancer in Palestine Study Overview This study highlights the importance of early nutrition for women newly diagnosed with breast cancer. It focused on how omega-3 fatty acids and vitamin D3 supplementation can improve their nutritional status. Methodology A total of 88 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of Postbiotic Bifidobacterium longum CECT 7347 on Gastrointestinal Symptoms, Serum Biochemistry, and Intestinal Microbiota in Healthy Adults: A Randomised, Parallel, Double-Blind, Placebo-Controlled Pilot Study
Effect of Postbiotic Bifidobacterium longum CECT 7347 on Digestive Health Study Overview This study evaluated the impact of heat-treated Bifidobacterium longum CECT 7347 (HT-ES1) on digestive symptoms in healthy adults. It was a randomised, double-blind, placebo-controlled trial with 60 participants over 8 weeks, followed by a check-in at week 10. Key Methods Researchers measured: Gastrointestinal […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling
Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease Study Overview This study looked at how 12 sessions of patient-specific adaptive dynamic cycling (PSADC) compared to non-adaptive cycling (NA) affected motor function and mobility in people with Parkinson’s disease (PD). We used advanced sensors to measure changes accurately. Methodology Twenty-three participants with […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTargeted Biofeedback Training to Improve Gait Parameters in Subacute Stroke Patients: A Single-Blind Randomized Controlled Trial
Targeted Biofeedback Training to Improve Gait in Stroke Patients Study Overview This study explores how biofeedback (BFB) training can help stroke patients regain their walking ability. BFB training uses specific walking targets to guide rehabilitation. Key Findings Stroke patients often have uneven walking patterns, especially during the stance phase. The study involved 60 participants: 40 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of customized insoles in the distribution of the diabetic foot pressure: A randomized and controlled clinical trial
Efficacy of Customized Insoles for Diabetic Foot Pressure Study Overview This study looked at how customized insoles affect foot pressure in patients with diabetic neuropathy. It compared results from patients using the insoles to those using a placebo over three and six months. Key Findings Background: Diabetic neuropathy can be detected early in patients with […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe application of directional preference for chronic non-specific knee pain: A pragmatic, controlled, randomized clinical trial
The Application of Directional Preference for Chronic Knee Pain Overview This study focused on chronic knee pain in Brazilian Jiu-Jitsu practitioners (BJJPs). It evaluated the effectiveness of the McKenzie Method of Mechanical Diagnosis and Therapy (MDT) using Directional Preference (DP) to improve function and reduce pain. Study Details Sixty-five BJJPs with chronic knee pain were […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Immediate effects of soft tissue mobilization and percussive massage on balance in young adults with pes planus: A single blind, randomized controlled pilot study
Immediate Effects of Soft Tissue Mobilization and Percussive Massage on Balance in Young Adults with Pes Planus Study Overview This study looked at how two treatments, IASTM (Instrument Assisted Soft Tissue Mobilization) and PMT (Percussive Massage Therapy), affect balance in young adults with flat feet (pes planus). Methodology We diagnosed pes planus using the navicular […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effectiveness of manual therapy to the Cervical Spine on clinical outcomes and electrodiagnostic tests in people with carpal tunnel syndrome: A randomized controlled trial
Effectiveness of Manual Therapy for Carpal Tunnel Syndrome Study Overview This study aimed to find out if combining cervical spine manual therapy (CMT) with traditional physical therapy (PT) leads to better outcomes for people with carpal tunnel syndrome (CTS) compared to using PT alone. Methodology Forty-eight patients diagnosed with CTS were split into two groups: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of the scapula mobilization technique on the neural mechanosensitivity of the upper limb neural test 1 in individuals with mechanical cervicalgia. A randomized controlled trial
Effectiveness of Scapula Mobilization Technique for Cervical Pain Study Overview This study investigates whether scapula mobilization can improve nerve sensitivity in patients with neck pain (cervicalgia). Cervicalgia is localized neck pain caused by nerve root compression, often linked to muscles around the scapula. Methods We recruited 60 adults with cervicalgia and a positive upper limb […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA pilot randomized clinical trial examining the effects of Qigong on inflammatory status and sleep quality in people with Parkinson’s disease
A Pilot Study on Qigong for Parkinson’s Disease Background Neuroinflammation is a key factor in the decline of neurons in people with Parkinson’s disease (PD). High levels of inflammatory markers, like IL-1β, IL-6, and TNF-α, are common in PD patients and relate to various non-motor symptoms. Qigong, a mind-body exercise, has been used to help […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Carrageenan and insulin resistance in humans: a randomised double-blind cross-over trial
Carrageenan and Insulin Resistance in Humans: A Clinical Trial Overview Study Background This study investigates the effects of carrageenan, a common food additive, on insulin resistance and inflammation in humans. While it is known to cause issues in animal studies, its impact on human health is not fully understood. Study Design A total of 20 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of canagliflozin on brain natriuretic peptide levels in patients with type 2 diabetes on peritoneal dialysis in Japan: protocol for a multicentre, prospective, randomised controlled trial (CARD-PD trial)
Effects of Canagliflozin on Patients with Type 2 Diabetes on Peritoneal Dialysis Study Overview Patients with type 2 diabetes (T2D) who are on dialysis face a higher risk of death due to heart and blood vessel issues. This study looks at how a medication called canagliflozin, which is used for T2D, affects heart health in […] ➡️➡️➡️