Clinical trials

Study Overview OCD imposes significant burdens and has been exacerbated by the COVID-19 pandemic. This study aims to develop and validate a prevention program for at-risk adults utilizing cognitive-behavioral therapy and exposure response prevention techniques. Methods The study will involve a single-blind, randomized controlled trial comparing the prevention program to a waitlist control group. At-risk […] ➡️➡️➡️

Comparing Text Messaging and Pillbox Organizers for Heart Failure Medication Adherence Background Heart failure affects millions and non-adherence to medication is a common problem. New reminders like text messaging show promise in improving adherence. Methods 189 heart failure patients were randomly assigned to tailored text messaging (TTM), pillbox organizers, or control. Medication adherence was measured […] ➡️➡️➡️

Cryoneurolysis versus Radiofrequency Ablation for Chronic Low Back Pain Key Findings: A study compared cryoneurolysis and radiofrequency (RF) with a placebo for patients with chronic low back pain. The primary goal was to assess patient global impression of change (PGIC), pain intensity, function, and quality of life over a 1-year period. Study Design: The research […] ➡️➡️➡️

Managing Children with Frequent Respiratory Infections and Wheezing: A New Study Background Preschoolers often suffer from respiratory infections (RIs) leading to wheezing. This study explores the effectiveness and safety of a new multi-component nasal spray in treating these symptoms. Methods Preschoolers were either given the new nasal spray (Saflovir) or standard therapy. The outcomes measured […] ➡️➡️➡️

Efficacy of Pulse Methylprednisolone in Treatment of Acute Respiratory Distress Syndrome due to Malaria: A Randomized Controlled Clinical Trial Objective The study aimed to assess the effectiveness of pulse methylprednisolone (MPS) therapy in patients with malaria-related acute respiratory distress syndrome (ARDS). Materials and Methods The trial involved 44 patients in a randomized, single-blind, placebo-controlled study. […] ➡️➡️➡️

Varying Clinical Effectiveness of Platelet-Rich Plasma Injections in Knee Osteoarthritis Objective: To study the effectiveness of single, triple, and quintuple platelet-rich plasma injections in patients with knee osteoarthritis. Methods: – 120 patients with knee osteoarthritis were divided into three groups: PRP1, PRP3, and PRP5. – Patients were evaluated using Visual Analogue Scale (VAS) and Western […] ➡️➡️➡️

Study Summary: Concentrated Growth Factor and Sodium Hyaluronate for Temporomandibular Joint Osteoarthritis Objective To assess the impact of concentrated growth factor (CGF) combined with sodium hyaluronate (SH) on temporomandibular joint osteoarthritis (TMJOA). Methods Sixty TMJOA patients were divided into control and experimental groups. The experimental group received CGF + SH, while the control group received […] ➡️➡️➡️

Effectiveness and Feasibility of 5G-Based Remote Interactive Ultrasound Training in Critical Care BMC Med Educ. 2024 May 8;24(1):514. doi: 10.1186/s12909-024-05485-0. Background: Ultrasound is extensively used in critical care, and remote ultrasound training through 5G technology is becoming more common. This study aimed to assess the effectiveness of 5G-based remote interactive ultrasound training for critical care […] ➡️➡️➡️

Effect of Er,Cr:YSGG Laser-Assisted Periodontal Therapy Practical Solutions and Value This clinical trial aimed to show the effectiveness of Er,Cr:YSGG laser-assisted therapy in treating periodontitis patients during the early healing period of 8 weeks. Key Findings The study involved 12 patients with advanced periodontitis, and the results showed that the laser-assisted therapy led to greater […] ➡️➡️➡️

Selenium Supplementation and Gestational Diabetes: A Randomised Controlled Trial Objective To evaluate the impact of selenium supplementation on blood glucose levels in women with gestational diabetes mellitus (GDM). Study Design Randomised controlled trial conducted at the Department of Internal Medicine, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkiye, from February to July 2023. Methodology Pregnant […] ➡️➡️➡️

Comparison of Anterior Cervical Discectomy and Fusion (ACDF) versus Cervical Disc Replacement (CDR) for Cervical Disc Disease Study Details: Researchers compared the radiological outcomes and development of heterotopic ossification (HO) in patients who underwent single-segment ACDF and CDR for cervical disc herniation to evaluate their impact on surgical success. Study Duration: January 2020 to June […] ➡️➡️➡️

TLR Agonists in Glioma Treatment: Clinical Trial Results Key Points: In a phase II clinical trial, TLR agonists poly-ICLC and resiquimod were combined with autologous tumor lysate-pulsed dendritic cell vaccination in patients with malignant gliomas. The goal was to assess the best combination to boost immune response while ensuring safety. The combination was safe and […] ➡️➡️➡️

Study Protocol for Evaluation of Calcium Dobesilate Efficacy on SARS-CoV-2 Viral Load in COVID-19 Outpatients Key Highlights The CADOVID trial aims to assess the effectiveness and safety of Calcium Dobesilate (CaD) in reducing SARS-CoV-2 viral load and mitigating persistent COVID-19 symptoms in non-hospitalized adult patients diagnosed with COVID-19. The trial is a randomized, placebo-controlled, double-blind, […] ➡️➡️➡️

Did diet compliance and remission reduce oxidative stress in celiac patients? Rev Assoc Med Bras (1992). 2024 May 3;70(4):e20231120 OBJECTIVE: This study aimed to investigate the impact of remission status on thiol-disulfide balance in celiac patients, providing insights into the effect of oxidative stress and inflammation resulting from non-compliance with the diet. METHODS: A total […] ➡️➡️➡️

Rapid and Sustained Antidepressant Effects of Intravenous Ketamine Key Findings Results from a clinical trial showed that intravenous ketamine led to rapid and significant improvements in symptoms of major depressive disorder (MDD) and suicidal ideation. Study Details The trial involved 64 patients with treatment-resistant MDD, who were randomly assigned to receive either ketamine or a […] ➡️➡️➡️

Efficacy and safety of 3D magnetically assisted capsule endoscopy (3D MACE) for upper gastrointestinal and small bowel examination Abstract Magnetically assisted capsule endoscopy (MACE) has shown potential for examining the upper gastrointestinal tract. This clinical study aimed to assess the efficacy and safety of a novel 3D MACE system for simultaneous upper gastrointestinal and small […] ➡️➡️➡️

Resistance Prehabilitation in Valvular Cardiac Surgery: A Clinical Trial Protocol Introduction Cardiovascular diseases (CVD) often require major surgery for treatment. Fast-track rehabilitation programs have shown promise in reducing postoperative complications and hospital stays. This study aims to assess whether adding resistance training (RT) to cardiac exercise-based prehabilitation can decrease intensive care unit (ICU) length of […] ➡️➡️➡️

Antibacterial Therapy for Acute Streptococcal Tonsillopharyngitis: Results of a Comparative Clinical Trial Background Acute tonsillopharyngitis is a common respiratory tract infection. Penicillin antibiotics like amoxicillin + clavulanic acid are often prescribed for bacterial causes. Dispersible forms of antibiotics have advantages over film-coated tablets, with better pharmacokinetic parameters, increasing effectiveness, safety, and patient compliance. Aim To […] ➡️➡️➡️

Phase 3b Study of Venetoclax and Azacitidine or Decitabine in Outpatient Setting for Acute Myeloid Leukemia Key Findings: Venetoclax combined with azacitidine or decitabine is approved for treating newly diagnosed acute myeloid leukemia (ND AML) in patients unable to undergo intensive chemotherapy. This study assessed the effectiveness and safety of this combination in a community-based […] ➡️➡️➡️

Summary of DIATEC Trial: Improving In-Hospital Diabetes Management Background Up to 20% of hospitalized patients have diabetes, leading to increased mortality, morbidity, and hospital stays. The DIATEC trial aims to improve in-hospital diabetes management strategies. Methods The trial is a two-armed, two-site, prospective randomised open-label blinded endpoint (PROBE) trial. Non-critically ill hospitalised patients with type […] ➡️➡️➡️