Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of low-load resistance training with blood flow restriction vs. conventional high-intensity resistance training in older people diagnosed with sarcopenia: a randomized controlled trial
Study Overview This study examined how effective low-load resistance training with blood flow restriction (LRT-BFR) is compared to conventional high-intensity resistance training (CRT) for older adults with sarcopenia. Key Findings Participants: 21 older adults (65 years and older) diagnosed with sarcopenia. Training Groups: LRT-BFR: 20%-30% of one-repetition maximum (1RM) CRT: 60%-70% of 1RM Duration: 12 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparing standard- and low-dose CBCT in diagnosis and treatment decisions for impacted mandibular third molars: a non-inferiority randomised clinical study
Study Overview This study compares the effectiveness of standard-dose and low-dose cone-beam computed tomography (CBCT) in diagnosing and treating impacted mandibular third molars (M3Ms). Objective The goal was to see how well low-dose CBCT shows the mandibular canal (MC) and its closeness to M3Ms, and how this affects decisions made by dental professionals. Methods A […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA synbiotic mixture for the management of infantile colic: A randomized trial
A Synbiotic Mixture for Managing Infantile Colic Study Overview This study investigates the effectiveness of a synbiotic (Bactecal D Liquid) for infants experiencing colic, which is characterized by excessive crying and irritability. A total of 68 infants were involved in a randomized trial, where they received either one or two doses of the synbiotic daily […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical efficacy observation of heat-sensitive moxibustion combined with intrapleural perfusion of cisplatin in treatment of malignant pleural effusion
Clinical Study on Moxibustion and Cisplatin for Malignant Pleural Effusion Objective The study aimed to assess the effectiveness of combining heat-sensitive moxibustion with intrapleural cisplatin infusion compared to cisplatin infusion alone in treating malignant pleural effusion (MPE). Methods Forty patients with MPE were randomly divided into two groups: an observation group (20 patients) and a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseHand-Arm Bimanual Intensive Therapy Including Lower Extremities in Infants With Unilateral Cerebral Palsy: A Randomized Clinical Trial
Hand-Arm Bimanual Intensive Therapy for Infants with Unilateral Cerebral Palsy Study Overview This clinical trial aimed to find out if the Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) can help improve motor skills in infants with unilateral cerebral palsy (UCP). Why It Matters Identifying cerebral palsy early and using effective therapies can significantly enhance […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCorrelation of CTCAE and patient-reported breast radiation dermatitis symptom scores
Correlation of CTCAE and Patient-Reported Breast Radiation Dermatitis Symptoms Study Overview This study looks at how the CTCAE scale, used by doctors to grade radiation dermatitis (RD), relates to symptoms reported by patients. It examines the connection between CTCAE scores and patient experiences using two assessment tools: the Skin Symptom Assessment (SSA) and the Radiation-Induced […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEmbodied cognition driven Qigong: a cross-sectional study and a pilot randomized controlled trial on managing depression and preventing relapse in substance dependence
Embodied Cognition Driven Qigong: Managing Depression and Preventing Relapse in Substance Use Disorders Objective Substance use disorders (SUDs) are a major public health issue, with high relapse rates. This study aimed to explore factors that influence relapse and to test a Health Qigong intervention to help manage these issues. Methods We surveyed 398 male substance […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Immunogenicity of adalimumab reference product and adalimumab-adbm in patients with rheumatoid arthritis, Crohn’s disease and chronic plaque psoriasis: a pooled analysis of the VOLTAIRE trials
Immunogenicity of Adalimumab Reference Product vs. Adalimumab-adbm Study Overview This analysis looked at the immunogenicity of a biosimilar drug, adalimumab-adbm (Cyltezo), compared to the original adalimumab (Humira) in patients with rheumatoid arthritis, Crohn’s disease, and chronic plaque psoriasis. Study Details In the VOLTAIRE trials, researchers measured the presence of antidrug antibodies (ADAs) and neutralizing antibodies […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAccuracy of healthcare systems data for identifying cardiovascular outcomes after stroke due to intracerebral haemorrhage in the United Kingdom
Accuracy of Healthcare Data in Identifying Cardiovascular Outcomes After Stroke Background Healthcare systems data (HCSD) can make clinical trials more efficient, but their accuracy is not always clear. This study aimed to evaluate how accurate HCSD is for detecting outcomes in the RESTART trial, comparing it to follow-up questionnaires. Methods RESTART was a clinical trial […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of flaxseed consumption and fasting mimicking diet on anthropometric measures, biochemical parameters, and hepatic features in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): a randomized controlled clinical trial
Effectiveness of Flaxseed and Fasting Mimicking Diet in Managing MASLD Study Overview This study explored how combining flaxseed and a fasting mimicking diet (FMD) affects patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). While both treatments have shown benefits individually, their combined effect was unclear. Study Design Conducted over 12 weeks, this randomized trial involved […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe Effect of High-Intensity Interval Training on Quality of Life and Incidence of Chemotherapy Side Effects in Women With Breast Cancer
The Effect of High-Intensity Interval Training on Quality of Life and Chemotherapy Side Effects in Women With Breast Cancer Study Overview This study focuses on how high-intensity interval training (HIIT) affects the quality of life and side effects of chemotherapy in women with breast cancer (BC). Women undergoing neoadjuvant chemotherapy (NAC) often face various symptoms […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSelective nociceptive modulation using a novel prototype of transcutaneous kilohertz high-frequency alternating current stimulation: a crossover double-blind randomized sham-controlled trial
Selective Nociceptive Modulation with Transcutaneous KHFAC Stimulation Background Kilohertz high-frequency alternating current (KHFAC) stimulation is a method that can block nerves quickly without causing harm. Previous studies have tested frequencies from 5 to 20 kHz in humans, but few devices are approved for higher frequencies. This study aims to evaluate a new device that can […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effects of exercise and dietary interventions on asprosin, leptin, and lipid metabolism in males with abdominal obesity, a randomized controlled trial
Effects of Exercise and Diet on Abdominal Obesity Study Overview This study focused on how exercise and diet impact health markers in men with abdominal obesity. It involved 44 males, average age 34.7 years, who were divided into three groups: Exercise Group (EG): 16 participants did aerobic-resistance exercise for 6 weeks. Exercise + Diet Group […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of treatment for concussion-related convergence insufficiency: The CONCUSS study protocol for a randomized clinical trial
Effectiveness of Treatment for Concussion-Related Convergence Insufficiency: The CONCUSS Study Study Overview The CONCUSS study is a clinical trial that aims to compare two treatment approaches for concussion-related convergence insufficiency (CONC-CI). It will evaluate: Immediate Office-Based Vergence/Accommodative Therapy with Movement (OBVAM) Delayed OBVAM (starting six weeks later) The study will also explore how the timing […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effectiveness of the Offer of the Smoke Free Smartphone App Compared With No Intervention for Smoking Cessation: Pragmatic Randomized Controlled Trial
Effectiveness of the Smoke Free Smartphone App for Smoking Cessation Study Overview This study examined how effective the Smoke Free app is in helping people quit smoking compared to not receiving any support. Background Digital tools, like apps, can provide affordable ways to help people stop smoking. Study Objective We wanted to see if offering […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseUtilization of Psychiatric Hospital Services Following Intensive Home Treatment: A Nonrandomized Clinical Trial
Utilization of Psychiatric Hospital Services Following Intensive Home Treatment A Nonrandomized Clinical Trial Importance: Home treatment (HT) has been linked to fewer days in the hospital but lacks proof of reducing overall psychiatric hospital service use (including inpatient treatment, home treatment, and day clinics). Objective: This study aimed to compare intensive home treatment (IHT) with […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effects of long-term almond consumption on markers for vascular function and cardiometabolic risk in men and women with prediabetes: results of a randomized, controlled cross-over trial
Effects of Long-Term Almond Consumption on Health Study Overview This study looked at how eating almonds over a long time affects blood vessel health and heart-related risks in people with prediabetes. The research involved 34 participants who took part in a controlled trial with two phases: one where they ate almonds daily and another without […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effects of curcumin supplementation on inflammatory markers in systemic lupus erythematosus patients: a randomized placebo-controlled trial
The Impact of Curcumin on Inflammation in Lupus Patients Study Overview This study focused on how curcumin, a compound from turmeric, affects inflammation in patients with systemic lupus erythematosus (SLE), a chronic autoimmune disease. Study Design Seventy SLE patients aged 18-60 participated in this randomized, triple-blinded, placebo-controlled trial. Out of these, 62 completed the study. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Impact of L-carnitine supplementation on gastric emptying and bowel function in pediatric ketogenic diet therapy: a clinical trial
Impact of L-carnitine Supplementation on Children on a Ketogenic Diet Study Overview The ketogenic diet (KD) is high in fat, moderate in protein, and low in carbohydrates. This diet can affect how the stomach empties and how quickly food moves through the intestines. Purpose of the Trial The main goal of this clinical trial was […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMulticentre randomised controlled trial comparing Bankart repair with remplissage and Latarjet procedure in shoulder instability with subcritical bone loss (STABLE): study protocol
Multicentre Randomised Controlled Trial on Shoulder Instability (STABLE): Study Overview Introduction Recurrent shoulder dislocations can damage the labrum and lead to bone loss in the shoulder. There are two main treatment options: soft tissue repair and bone augmentation. However, the best treatment for patients with some bone loss is still unclear, and current practices vary […] ➡️➡️➡️