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Study Summary
There is a need for non-invasive biomarkers to track airway inflammation in cystic fibrosis (CF) patients. Urinary glutathione sulfonamide (GSA) levels show promise in correlating with inflammation markers and may be suitable for monitoring disease activity.
Study Objectives
- Explore changes in urinary GSA levels during hospital admission for acute pulmonary exacerbation or eradication of infectious agents in CF patients.
- Assess the correlation between urinary GSA levels and clinical factors such as sex and infection status.
Methodology
- 102 children and 64 adults admitted to the hospital were included in the study.
- Urine samples collected at admission and discharge were analyzed for GSA using liquid chromatography with mass spectrometry.
- Comparison of paired admission-discharge results was done using statistical tests.
Key Findings
- Statistically significant differences in urinary GSA levels were observed between admission and discharge for both children and adults.
- Correlation analysis showed a link between urinary GSA levels and sex and Staphylococcus aureus infection in children.
Implications
Urinary GSA levels appear to be responsive to the resolution of acute pulmonary exacerbation in CF patients, indicating the need for further research in this area.
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