Evaluating Subthreshold Micropulse Laser Combined with Ranibizumab for Diabetic Macular Edema
Study Overview
A study was conducted to assess the effectiveness and safety of using subthreshold micropulse laser (SMPL) in combination with ranibizumab for treating diabetic macular edema (DME). Patients were randomly assigned to receive either ranibizumab monotherapy or the combination therapy.
Key Findings
- Both treatment groups showed significant improvement in visual acuity and reduction in central macular thickness at 6 and 12 months.
- No statistically significant difference was observed between groups for these measures.
- Combination therapy led to a significant increase in vessel density of the deep capillary plexus (DCP), compared to ranibizumab monotherapy.
- Ranibizumab monotherapy group required more intravitreal injections compared to the combination therapy group.
- No adverse events were reported during the follow-up period.
Conclusion
The study concluded that the combination of SMPL with ranibizumab injections was effective and safe for treating DME. It also reduced the number of injections needed and improved vessel density and macular ischemia compared to ranibizumab monotherapy.
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