Comparison of Kidney Damage in Different Colorectal Cancer Surgeries
Study Overview
Colorectal cancer is the third most common cancer affecting both men and women. With new technologies, less invasive surgical options are becoming more popular. This study compares kidney damage between laparoscopic (minimally invasive) and open surgeries for colon and rectal cancer using a specific marker called kidney injury molecule-1 (KIM-1).
Study Details
We included 46 colon cancer patients who underwent either laparoscopic or open surgery at our clinic. Patients were randomly divided into five groups:
- Group 1: 10 laparoscopic right hemicolectomies
- Group 2: 8 open right hemicolectomies
- Group 3: 8 laparoscopic anterior resections
- Group 4: 11 open anterior resections
- Group 5: 9 laparoscopic low anterior resections
We collected urine samples before surgery, 4 hours after, and on the 14th day after surgery to measure KIM-1 and creatinine levels. We calculated the KIM-1/creatinine ratios for analysis.
Key Findings
After surgery, KIM-1/creatinine levels increased for both surgical methods. However, by the 14th day post-surgery, these levels were lower than before surgery in all groups, except for those who underwent laparoscopic anterior resections.
Conclusion
Our findings indicate that laparoscopic surgeries do not cause long-term kidney damage compared to open surgeries.
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