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Study Title: Comprehensive Analysis of Neoadjuvant Camrelizumab and Chemotherapy for Locally Advanced Gastric Cancer
Background
The study aimed to evaluate the effectiveness of combining neoadjuvant camrelizumab with chemotherapy in treating locally advanced gastric cancer. This approach is being explored as a potential alternative to the current standard treatment.
Methods
The study involved a single-arm, phase 2 trial to assess the response to the combined treatment and identify potential biomarkers of response through multi-omics analysis. The primary endpoint was the pathological complete response rate, and secondary endpoints included survival rates. Multi-omics analysis was conducted using various sequencing techniques and immunofluorescence imaging.
Results
Out of 60 patients, 9.1% achieved a complete pathological response, and 20% achieved near complete response. The combined treatment showed manageable safety and tolerability, with identified molecular changes correlating with treatment response. The study also revealed associations between specific genetic mutations and treatment sensitivity, as well as immune cell infiltration analysis.
Conclusion
The study suggests that the combination of PD-1 inhibitor and chemotherapy demonstrated efficacy and acceptable safety for locally advanced gastric cancer. Further follow-up is needed to determine the duration of the response.
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