Objective
We studied how tumor cells behave in Chinese patients with mantle-cell lymphoma (MCL) and found they may grow faster than in Western patients. To address this, we designed a clinical trial to test a new treatment combining R-DA-EDOCH immunochemotherapy and R-DHAP therapy in young patients with newly diagnosed MCL.
Methods
We included 55 patients in our study. At the end of the treatment, 89.1% of patients achieved complete remission, and 98.1% showed a positive response. Most patients with cancer in their bone marrow quickly reached a state where trace cancer cells were undetectable.
Results
Three years after treatment, 66.3% of patients remained free of cancer progression, and 83.2% were still alive. Importantly, no patient stopped treatment due to side effects. We found certain factors, like specific mutations, could affect progression-free survival, but others did not seem to impact outcomes significantly.
Conclusions
This intensive therapy using high doses of a specific drug successfully achieved high rates of remission and offers a strong treatment option for young patients with high-risk MCL.
Opportunities Based on Trial Data
To improve cancer care, we can:
- Define Measurable Outcomes: Set clear goals for achieving deep remission in patients with MCL.
- Select AI Tools That Fit Clinical Needs: Choose AI solutions appropriate for specific tasks in treatment management.
- Implement Step by Step and Expand: Begin with small pilot projects and track results using AI to measure real-world impacts based on our research findings.
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