Did diet compliance and remission reduce oxidative stress in celiac patients?


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Did diet compliance and remission reduce oxidative stress in celiac patients?

Rev Assoc Med Bras (1992). 2024 May 3;70(4):e20231120

OBJECTIVE: This study aimed to investigate the impact of remission status on thiol-disulfide balance in celiac patients, providing insights into the effect of oxidative stress and inflammation resulting from non-compliance with the diet.

METHODS: A total of 117 celiac disease patients were enrolled in a prospective randomized and controlled study between February 2019 and December 2021. Thiol and disulfide levels were measured in the blood at the beginning of the study and at the end of the first year, in addition to routine tests for celiac patients.

RESULTS: Of the patients, 52 (44.4%) were in remission, while 65 (55.6%) were not. Patients initially not in remission but achieving remission at the end of the first year showed a significant increase in native thiol levels (347.4±46.7 μmol/L vs. 365.3±44.0 μmol/L; p=0.001). Furthermore, mean plasma disulfide levels in patients achieving remission decreased from 14.5±5.1 μmol/L to 8.9±4.2 μmol/L (p<0.001) in the first year. For celiac patients entering remission, a correlation was observed between reduced disulfide and anti-tissue transglutaminase immunoglobulin A levels (r=0.526; p<0.001).

CONCLUSION: Non-remission in celiac disease leads to increased oxidative stress, and thiol-disulfide balance serves as an indirect indicator. Achieving remission in celiac patients contributes to reducing oxidative stress.

PMID: 38716937 | DOI: 10.1590/1806-9282.20231120

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