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Practical Solutions and Value
Practical Solutions
- Developed a fast and accurate method to quantify pyronaridine in whole blood
- Reduced sample volume required to 50 µL
- Eliminated matrix effect and ion enhancement or suppression
- Improved sensitivity and reduced carry-over in the chromatographic system
Value
- Supported future PK studies of pyronaridine, especially in special populations like children and pregnant women
- Enabled assessment of the terminal elimination half-life of pyronaridine up to 42 days post-treatment initiation
- Enhanced sensitivity for accurate quantification of pyronaridine in whole blood
- Demonstrated stability of pyronaridine for up to 315 days when stored at -70°C
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