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Effect of ertugliflozin on left ventricular function in type 2 diabetes and pre-heart failure: the Ertu-GLS randomized clinical trial

Effect of Ertugliflozin on Heart Function in Type 2 Diabetes and Pre-Heart Failure

Study Overview

This study investigates how well ertugliflozin, a type of medication for diabetes, works on heart function for people with type 2 diabetes and early signs of heart failure.

Study Design

In this randomized, double-blind trial lasting 24 weeks, we had participants with type 2 diabetes not well-controlled by other medications. Those with heart issues were divided into two groups: one received ertugliflozin (5 mg once daily), and the other received a placebo. The main goal was to see changes in heart function, measured by left ventricular global longitudinal strain (LVGLS). Secondary aims included heart size and pumping efficiency.

Key Findings

  • 102 participants were included, average age 63.9 years; 38% were women.
  • The ertugliflozin group showed a significant improvement in LVGLS compared to the placebo group (P = 0.013).
  • Improvements in heart size and pumping efficiency were also noticed.
  • Other benefits included lower blood sugar levels, reduced blood pressure, and decreased fat and uric acid levels.
  • Safety profiles were similar across both groups, with no major issues reported.

Conclusion

Ertugliflozin positively impacts heart function in individuals with type 2 diabetes and early heart failure signs, suggesting potential benefits for managing heart health.

Clinical Trial Registration

ClinicalTrials.gov Identifier: NCT03717194

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