ER-Targeted PET for Initial Staging and Suspected Recurrence in ER-Positive Breast Cancer
JAMA Netw Open. 2024 Jul 1;7(7):e2423435. doi: 10.1001/jamanetworkopen.2024.23435.
Objective: To compare the detection rate of 16α-18F-fluoro-17β-estradiol (FES) positron emission tomography (PET) computed tomography (CT) with standard-of-care imaging (SOC) for staging locally advanced breast cancer (LABC) or evaluating suspected recurrence in ER-positive breast cancer.
Design, Setting, and Participants: This diagnostic study conducted a single-center phase 2 trial from January 2021 to September 2023, including patients with ER-positive LABC or suspected recurrence.
Exposure: Participants underwent both SOC imaging and experimental FES PET/CT. Suspected lesions were biopsied for histopathological reference standard.
Main Outcomes and Measures: The detection rate of FES PET/CT vs SOC for distant metastases and recurrences.
Results: No significant difference was found between FES PET/CT and current SOC imaging for detecting distant metastases or recurrences in ER-positive breast cancer. FES PET/CT could be considered for both clinical indications, with potential benefits in patients with lobular tumors and lower false positives than current SOC imaging.
Conclusions and Relevance: FES PET/CT shows promise for detecting distant metastases and recurrences in ER-positive breast cancer, warranting further investigation for potential clinical use.
PMID: 39058489 | DOI: 10.1001/jamanetworkopen.2024.23435
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