Feasibility and accuracy of mobile QT interval monitoring strategies in bedaquiline-enhanced prophylactic leprosy treatment
Highlights
– Evaluation of alternative strategies for QT interval monitoring in settings where electrocardiographic monitoring is challenging
– Use of mobile electrocardiogram (mECG) device and automated measurements in phase II randomized controlled BE-PEOPLE trial
– 97% of recorded mECGs were of sufficient quality for QTc measurement
– Mean absolute QTc difference between mECG and 12L-ECG was 11 ± 10 ms
– mECG device yielded a median absolute QTc error of 8 ms, while automated measurements were less accurate
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