Hydromorphone combined with ropivacaine for erector spinae plane block in patients undergoing modified radical mastectomy: A prospective randomized controlled trial
Medicine (Baltimore). 2024 Jun 28;103(26):e38758. doi: 10.1097/MD.0000000000038758.
Background: Combining hydromorphone with ropivacaine in ultrasound-guided erector spinae plane blocks enhances postoperative pain relief and reduces interleukin-6 expression in breast surgery patients.
Methods: Breast cancer patients undergoing modified radical mastectomy were divided into 3 groups for anesthesia: standard general (group C), Erector Spinae Plane Block (ESPB) with ropivacaine (group R), and ESPB with ropivacaine plus hydromorphone (group HR). The study compared pain levels, IL-6 expression, anesthetic doses, additional analgesia needs, and recovery milestones to assess the efficacy of the ESPB enhancements.
Results: The group receiving hydromorphone with ropivacaine (group HR) showed significantly lower IL-6 levels, reduced anesthetic doses, lower pain scores, reduced need for additional analgesia, and faster recovery compared to the other groups.
Conclusion: Hydromorphone combined with ropivacaine for ESPB provided superior postoperative pain relief and recovery for patients undergoing modified radical mastectomy under general anesthesia. This combined analgesic approach resulted in fewer side effects and more effectively reduced IL-6 levels, promoting better postoperative recovery.
PMID:38941366 | DOI:10.1097/MD.0000000000038758
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