Study Overview
This research compared the effects of Estetrol (E4) combined with Drospirenone (DRSP) versus Ethinyl estradiol (EE) combined with DRSP on blood coagulation and fibrinolysis in Japanese patients with endometriosis.
Key Findings
– E4/DRSP combination showed significantly less impact on coagulation and fibrinolysis compared to EE/DRSP.
– Major anticoagulant proteins were less reduced in the E4/DRSP group.
– Thrombin generation was 4-fold higher in the EE/DRSP group.
– The fibrinolysis cascade was more activated in the EE/DRSP group, as indicated by higher D-dimer levels.
Practical Solutions & Value
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Streamlining Operations
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