Kisspeptin Expression Levels in Patients with Placenta Previa: A Randomized Trial
Medicine (Baltimore). 2024 Jul 12;103(28):e38866. doi: 10.1097/MD.0000000000038866.
Background: This study aimed to investigate the impact of kisspeptin (KISS1) levels on the development of placenta previa for early pregnancy diagnosis.
Methods: The study included 20 pregnant women diagnosed with placenta previa and 20 pregnant women with normal pregnancies between 2021 and 2022. Plasma KISS1 levels were analyzed biochemically, and genetic analysis assessed KISS1 and KISS1 receptor gene expression levels. Immunohistochemical methods were used to determine placenta KISS1 levels.
Results: The evaluation of KISS1 concentration in serum showed a significant decrease in the placenta previa group compared to the control group (P < .001). KISS1 gene expression level was 0.043-fold decreased in the placenta previa group (P < .001). Additionally, the KISS1 receptor gene expression level increased 170-fold in the placenta previa group.
Conclusions: Biochemical, immunohistochemical, and genetic analyses consistently indicated significantly reduced KISS1 expression in patients with placenta previa. These findings suggest a potential link between diminished KISS1 levels and the occurrence of placenta previa, indicating a critical role for KISS1 in its etiology. Further detailed studies on angiogenesis, cell migration, and tissue modeling are needed to understand potential mechanisms.
PMID:38996103 | DOI:10.1097/MD.0000000000038866
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