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Study Summary
This study aims to understand the impact of matrix metallopeptidase-9 (MMP9) on arterial smooth muscle cells, atherosclerosis development in diabetic mice, and drug-naïve diabetes patients.
Practical Solutions and Value
- Adding active human MMP9 to smooth muscle cells increased inflammation and initiated atherosclerosis in diabetic mice.
- In newly diagnosed drug-naïve diabetes patients, serum MMP9 levels were found to correlate with the size of carotid artery plaques and the severity of coronary artery issues.
- These findings suggest that MMP9 could serve as a potential biomarker for early identification of atherosclerosis in patients with diabetes.
Clinical Trial Registration
Find more details about the clinical trial at clinicaltrials.gov with the identifier NCT04424706.
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