Minimally invasive compared to open surgery in patients with low-risk cervical cancer following simple hysterectomy: An exploratory analysis from the Gynegologic Cancer Intergroup/Canadian Cancer Trials Group CX.5/SHAPE trial

Minimally Invasive Surgery for Low-Risk Cervical Cancer

Study Overview

This study examines whether minimally invasive surgery (MIS) is safe for women with low-risk cervical cancer who have undergone simple hysterectomy. It builds on previous findings that showed worse outcomes for MIS in early-stage cervical cancer patients.

Research Methods

The analysis included 338 patients from the Simple Hysterectomy And Pelvic Node Assessment trial. We compared clinical outcomes of patients who had MIS (281 patients) versus those who had open surgery (57 patients). Key factors included age, race, health status, and cancer characteristics.

Results Summary

After a median follow-up of 4.5 years:

  • Recurrences were similar: 12 (4.3%) in MIS group vs. 3 (5.3%) in open surgery group.
  • Patients who had MIS had fewer instances of residual disease in the hysterectomy specimen.
  • No significant differences were found in pelvic and extra-pelvic recurrence-free survival, overall recurrence-free survival, or overall survival between the two groups.

Conclusion

The findings suggest that MIS does not lead to worse outcomes for low-risk cervical cancer patients. However, since this was not a randomized study, more research is needed to confirm these results before recommending MIS as a standard approach.

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