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Study Summary: Identifying Biomarkers for Liver Cancer Diagnosis and Prognosis
The study aimed to find specific non-invasive biomarkers for early diagnosis, prognosis, and treatment response in patients with hepatocellular carcinoma (HCC).
Study Methods
- 42 HCC patients from the SORAMIC clinical trial were included.
- Patients received either sorafenib monotherapy or 90Y radioembolization in combination with sorafenib.
- Plasma samples were collected before and 7-9 weeks after treatment.
- Small RNA sequencing and next-generation sequencing were performed to identify disease-specific microRNA (miRNA) patterns.
Key Findings
- 42 differentially expressed miRNAs were identified when comparing baseline and control group plasma samples.
- Specific miRNAs were found to be up-regulated and down-regulated at different stages of treatment, providing potential diagnostic and prognostic value.
- High expression of hsa-miR-215-5p was associated with worse prognosis for HCC patients.
Conclusions
The study revealed potential miRNA biomarkers for diagnosing hepatocellular carcinoma and predicting survival in patients treated with sorafenib.
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