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Multilevel Intervention to Support Tailored and Responsive HIV Pre-Exposure Prophylaxis Care in Rural North Carolina: Protocol for a Randomized Controlled Trial

Background

Access to pre-exposure prophylaxis (PrEP) is crucial for reducing HIV cases in the U.S. However, certain groups, such as young people and minorities in North Carolina, are not using PrEP as much as they should. In 2018, the South had over half of new HIV diagnoses but only a third of PrEP users. This study aims to improve PrEP access in rural areas where healthcare services are limited.

Objective

This study will test a new approach to help people start using PrEP. We will recruit participants from rural and periurban STI clinics and provide them with a digital health app, a remote PrEP navigator, and telehealth services.

Methods

We plan to enroll up to 336 participants and divide them into two groups: one receiving the new intervention and the other receiving standard care. We will track their progress for at least three months to see how many start using PrEP and how well they engage with care.

Results

Enrollment began on August 31, 2023, and will continue until May 2025. We will share our findings after data collection is complete.

Conclusions

This study aims to overcome barriers to PrEP use in underserved areas, helping to inform future healthcare policies and programs.

Opportunities Based on Trial Data

We can identify measurable outcomes and set clear goals for clinics and patients to improve PrEP access and usage.

Selecting AI Tools

Choose AI solutions that meet specific clinical needs to enhance the effectiveness of the intervention.

Implementation

Start with a pilot project, monitor results using AI tools, and evaluate the real-world impact of the intervention.

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