Functional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression

Functional Changes in Sleep-Related Arousal After Ketamine Administration

Study Details

The study examined the effects of ketamine on sleep and mood in individuals with treatment-resistant depression.

Research Objectives

The aim was to compare sleep metrics between individuals with treatment-resistant major depression (TRD) and healthy volunteers, and to assess whether ketamine normalizes arousal in TRD. Additionally, the study sought to determine if ketamine’s effects on arousal relate to its antidepressant and anti-suicidal ideation (SI) effects.

Method

This secondary analysis was part of a biomarker-focused, randomized, double-blind, crossover trial of ketamine (0.5 mg/kg) compared to saline placebo. Polysomnography (PSG) studies were conducted before and after ketamine/placebo infusions.

Key Findings

Individuals with TRD had lower total sleep time (TST) and shorter rapid eye movement (REM) latency compared to healthy volunteers at baseline. Ketamine showed temporal effects on delta power during sleep, earlier and later in the night. However, there were no significant differences in the temporal patterns of alpha, beta, or delta power, and no mediation effects of sleep variables on ketamine’s antidepressant or anti-SI effects.

Implications

These results emphasize the role of sleep-related variables in the neurobiological changes initiated after ketamine administration.

Clinical Trials Identifier: NCT00088699

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