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Introduction
The elderly are at higher risk of severe illness and death from COVID-19. About 20% of older adults may not have antibodies three to five months after their second COVID-19 vaccine dose. This study investigates whether probiotics can help boost antibody levels after vaccination.
Study Overview
This study is a randomized controlled trial involving 688 adults aged 65-89 in Quebec, Canada. None of the participants will have had COVID-19 in the three months before joining the study. They will receive a government-recommended mRNA booster vaccine (Pfizer-BioNTech or Moderna) along with a daily probiotic or a placebo for 15 days before and after vaccination.
Methods
Participants will provide blood and stool samples at three points: when they join the study, three months later, and six months after vaccination. The main goal is to see how many participants lack antibodies six months post-vaccination. We will also track antibody levels over time and monitor any side effects from the probiotics and the vaccine.
Ethics and Approval
The study has received approval from the local ethics boards and Health Canada. Participants will give their consent before joining, and the results will be shared with the scientific community and relevant networks.
Expected Outcomes
We hope to determine if probiotics can enhance the immune response from vaccines in older adults. This could lead to better health outcomes and more effective vaccination strategies for seniors.
Next Steps
We will define measurable outcomes and establish clear goals based on the study findings. We will explore using AI tools to streamline processes and analyze results effectively.
Get in Touch
For more information about AI solutions in medical management, please contact us:
- Telegram: https://t.me/itinai
- X: https://x.com/vlruso
- LinkedIn: https://www.linkedin.com/company/itinai/
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