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Paraxanthine provides greater improvement in cognitive function than caffeine after performing a 10-km run

Paraxanthine Improves Cognitive Function After Exercise

Study Details

Researchers investigated the effects of paraxanthine (PX) and caffeine (CA) on cognitive function after exercise. PX, a caffeine metabolite, was found to enhance cognitive performance without the limitations of caffeine habituation and genetic sensitivity.

Method

12 trained runners were given different treatments in a double-blind, randomized, crossover manner, with a washout period between treatments. They underwent cognitive tests before and after exercise, as well as a 10-km run on a treadmill.

Results

The study found that PX ingestion led to improved prefrontal cortex function, attention, and reaction time, while mitigating cognitive fatigue. Combining CA with PX did not provide additional benefits.

Conclusion

These findings suggest that PX may offer a nootropic alternative to CA for improving cognitive function after exercise.

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