Conditions: Metastatic Castration-resistant Prostate Cancer
Sponsors: AstraZeneca; Merck Sharp & Dohme LLC
Recruiting
Real-World Clinical Experience of Patients With Metastatic Castration-Resistant Prostate Cancer Treated With Olaparib + Abiraterone (PROceed)
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Interactive AI Tools to Help You Understand Your Health
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Clinical Research
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Phase II Study of Ulixertinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Alterations: APEC1621J of the National Cancer Institute-Children’s Oncology Group Pediatric MATCH Trial
Phase II Study of Ulixertinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Alterations: APEC1621J of the National Cancer Institute-Children’s Oncology Group Pediatric MATCH Trial…
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Effects of exercise and dietary interventions on asprosin, leptin, and lipid metabolism in males with abdominal obesity, a randomized controlled trial
Effects of Exercise and Diet on Abdominal Obesity Study Overview This study focused on how exercise and diet impact health markers in men with abdominal obesity. It involved 44 males,…
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A group psychological intervention for postnatal depression in British mothers of South Asian origin — the ROSHNI-2 RCT
Background Postnatal depression is more common among British South Asian women than white women in the UK. Cognitive-behavioral therapy is known to be effective, but there is limited evidence on…
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Agomelatine as adjunctive therapy with SSRIs or SNRIs for major depressive disorder: a multicentre, double-blind, randomized, placebo-controlled trial
Background Many traditional antidepressants work well for some patients but not for everyone, especially those with major depressive disorder (MDD). Agomelatine is a different type of antidepressant that may help…
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Selective nociceptive modulation using a novel prototype of transcutaneous kilohertz high-frequency alternating current stimulation: a crossover double-blind randomized sham-controlled trial
Selective Nociceptive Modulation with Transcutaneous KHFAC Stimulation Background Kilohertz high-frequency alternating current (KHFAC) stimulation is a method that can block nerves quickly without causing harm. Previous studies have tested frequencies…
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Therapeutic effects of reduced glutathione on liver function, fibrosis, and HBV DNA clearance in chronic hepatitis B patients
Therapeutic Effects of Reduced Glutathione on Chronic Hepatitis B Objective This study aimed to assess how reduced glutathione, when combined with entecavir, affects liver function, fibrosis, and HBV-DNA clearance in…
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Comparison of established and preliminarily proposed ASAS MRI working group cut-offs for inflammatory MRI lesions in the sacroiliac joints in radiographic and non-radiographic axial spondyloarthritis
Comparison of MRI Cut-offs for Inflammatory Lesions in Axial Spondyloarthritis Background A study compared the established and newly proposed MRI cut-offs for inflammatory lesions in the sacroiliac joints in patients…
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Individualized Nutritional Support Improves Cardiac Function and Nutritional Status of Elderly Heart Failure Patients
Background Chronic heart failure (CHF) can greatly reduce a patient’s quality of life and is costly for healthcare systems. This study looked at how personalized nutritional support from a specialized…
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Measuring clinically relevant change in apathy symptoms in ADMET and ADMET 2
Measuring Change in Apathy Symptoms in Alzheimer’s Disease Trials Study Overview This study focused on participants with Alzheimer’s disease (AD) to determine the minimal clinically important difference (MCID) in apathy…
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L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial
GLORIA Trial: Combining CXCL12 Inhibition and Radiotherapy in Glioblastoma Key Findings: The GLORIA trial combined radiotherapy with the CXCL12-neutralizing aptamer olaptesed pegol (NOX-A12) in patients with newly-diagnosed glioblastoma. The study…
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Effects of Ninjin’yoeito on Patients with Chronic Obstructive Pulmonary Disease and Comorbid Frailty and Sarcopenia: A Preliminary Open-Label Randomized Controlled Trial
Effects of Ninjin’yoeito on Patients with COPD and Comorbid Frailty and Sarcopenia Study Details Published in the International Journal of Chronic Obstructive Pulmonary Disease in May 2024, this study aimed…
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Effects of mindfulness-based cognitive therapy for Chinese adults with PTSD symptoms: protocol for a randomised controlled trial
Effects of Mindfulness-Based Cognitive Therapy for Chinese Adults with PTSD Symptoms: Protocol for a Randomised Controlled Trial Abstract Introduction: Mindfulness-based cognitive therapy (MBCT) has shown promise as a potential psychotherapy…
