Revefenacin Area Under the Curve Spirometry in Patients with Moderate to Very Severe COPD

Revefenacin Area Under the Curve Spirometry in Patients with Moderate to Very Severe COPD

Study Overview

This study focuses on the effectiveness of Revefenacin, a once-daily bronchodilator, in improving lung function in patients with chronic obstructive pulmonary disease (COPD). It highlights the importance of measuring lung function through various endpoints, including the area under the FEV1 vs time curve (FEV1 AUC), which shows how long and consistently the medication works.

Study Details

In this analysis, data from two Phase 3 trials were examined. Patients with moderate to very severe COPD were randomly assigned to receive either Revefenacin (175 μg) or a placebo once daily for 12 weeks. Lung function was measured at different intervals to assess the effectiveness of the treatment.

Key Findings

Out of the participants, 50 received Revefenacin and 47 received the placebo. The results showed that Revefenacin provided significant and sustained improvements in lung function over 24 hours. The differences in lung function measurements compared to the placebo were:

• FEV1 AUC0-2h: 282 mL
• FEV1 AUC0-12h: 220 mL
• FEV1 AUC12-24h: 205 mL
• FEV1 AUC0-24h: 212 mL

All results were statistically significant (P < 0.001).

Conclusion

This analysis confirms that Revefenacin offers lasting bronchodilation for patients with COPD. By evaluating additional endpoints in clinical trials, healthcare providers can make better treatment decisions.

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