Ritlecitinib: A Breakthrough in Vitiligo Treatment
Published in Arch Dermatol Res, a clinical trial showed that ritlecitinib, an oral JAK3/TEC family kinase inhibitor, significantly stabilized active lesions and repigmented stable lesions in patients with non-segmental vitiligo.
Key Findings:
- Ritlecitinib 50 mg demonstrated significant stabilization of depigmentation extent in both active and stable lesions compared to placebo.
- Stable lesions showed greater repigmentation after 24 weeks of treatment with ritlecitinib 50 mg.
- Ritlecitinib 50 mg increased expression of melanocyte markers in stable lesions and decreased Th1/Th2-related and co-stimulatory molecules in both stable and active lesions.
- Data confirmed at transcription/protein levels indicate that stable lesion repigmentation occurs early with ritlecitinib, while active lesions require stabilization of inflammation first.
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