Rucaparib vs. Chemotherapy for Relapsed Ovarian Cancer
Study Overview
The ARIEL4 trial compared rucaparib, a targeted therapy, to standard chemotherapy in women with relapsed ovarian cancer who have BRCA mutations. The main goal was to see if rucaparib could improve progression-free survival.
Study Details
This international study involved 64 hospitals across 12 countries. Women aged 18 and older with BRCA1 or BRCA2 mutations and who had undergone at least two chemotherapy treatments were included. Patients were randomly assigned to receive either rucaparib or chemotherapy.
Key Findings
- 349 patients participated: 233 received rucaparib and 116 received chemotherapy.
- Median overall survival was 19.4 months for rucaparib and 25.4 months for chemotherapy.
- Common side effects included anemia and neutropenia, but no new safety concerns were identified.
Practical Solutions and Value
This study emphasizes the need for better treatment strategies for patients who have progressed on PARP inhibitors. Understanding how to sequence treatments effectively can lead to improved outcomes for patients with advanced ovarian cancer.
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