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Study Overview
This study aimed to assess the impact of subthreshold micropulse laser (SML) in combination with anti-vascular endothelial growth factor (anti-VEGF) therapy for diabetic macular edema (DME).
Research Methods
- Reviewed eight studies involving 493 eyes
- Four were randomized controlled trials and four were retrospective studies
- Utilized meta-analysis to analyze best-corrected visual acuity (BCVA), central macular thickness (CMT), and the number of anti-VEGF injections
Key Findings
- No significant difference in BCVA between the two treatment groups
- CMT was marginally thinner in the anti-VEGF with SML group, but this was not consistently supported by additional analyses
- Significant reduction in the number of anti-VEGF injections in the anti-VEGF with SML group
Conclusion
The study suggests that adding SML to anti-VEGF therapy could notably decrease the number of injections required, without compromising BCVA and CMT outcomes compared to anti-VEGF monotherapy.
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