Symptomatic Improvement in Eosinophilic Esophagitis
Key Findings from Recent Study
Background: This study looked at why adults and teenagers with eosinophilic esophagitis (EoE) need more doses of dupilumab compared to other conditions.
Study Methods:
Researchers combined results from the phase 3 LIBERTY EoE TREET study, focusing on two main goals:
- Percentage of patients with 6 or fewer eosinophils per high-power field.
- Change in the Dysphagia Symptom Questionnaire score from the start.
Study Results:
They found that:
- Higher levels of dupilumab in the body initially led to a significant reduction in eosinophils at week 24.
- Symptomatic improvement continued to increase with higher dupilumab levels.
- Patients receiving the highest doses experienced more symptom relief, regardless of past treatments.
Conclusion:
The approved dupilumab regimen of 300 mg weekly for adults and adolescents with EoE weighing at least 40 kg is beneficial based on these findings.
Importance of Clinical Trials
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