ANODYNE Study Overview This study investigates the effectiveness of greater occipital nerve block (GONB) using methylprednisolone and lignocaine for preventing episodic cluster headaches. Background There is limited evidence on how well GONB works for treating cluster headaches. This study aimed to evaluate its effectiveness and safety as a transitional preventive treatment. Methods Conducted in New…
Prognostic Impact of Admission Time in Infarct-Related Cardiogenic Shock Study Overview This study looks at how the timing of hospital admission affects patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS) and the effectiveness of extracorporeal life support (ECLS). Key Objectives The goal was to compare outcomes for patients admitted during regular hours (on-hours)…
N-acetylcysteine Supplementation for PCOS Study Overview Polycystic ovary syndrome (PCOS) affects 6-20% of women globally. Many women with PCOS experience insulin resistance and high insulin levels, which worsen oxidative stress and contribute to the condition. N-acetylcysteine (NAC) is an antioxidant that may help treat PCOS. This study looked at how NAC affects metabolic health in…
The Impact of Synbiotics on Drug-Resistant Epilepsy and Caregiver Stress Study Overview This study explored how synbiotics can help children with drug-resistant epilepsy (DRE) and ease the stress on their caregivers. Synbiotics are a mix of probiotics and prebiotics that support gut health. Study Details Conducted in Arak, Iran with 30 children diagnosed with DRE.…
Implementing a Remote Self-Screening Program for Atrial Fibrillation Overview This study evaluates how feasible it is to use digital health technology for self-screening of atrial fibrillation (AF) in older adults living in the community, specifically those aged 75 and older. Study Design The research involved a process evaluation of the Mass AF clinical trial, using…
Nivolumab+AVD in Advanced-Stage Classic Hodgkin’s Lymphoma Study Overview This study compares two treatments for advanced-stage classic Hodgkin’s lymphoma: Brentuximab vedotin combined with AVD (BV+AVD) Nivolumab combined with AVD (N+AVD) Brentuximab can improve outcomes but may lead to more side effects and challenges with relapses. Nivolumab has shown effectiveness, especially in previously untreated patients. Trial Details…
Upper- vs Lower-Extremity Secondary Access During Transcatheter Aortic Valve Implantation: A Randomized Clinical Trial Importance The upper-extremity method for secondary access during Transcatheter Aortic Valve Implantation (TAVI) may lower the risk of bleeding at the access site. Objective This study aimed to compare the safety and effectiveness of upper-extremity access versus lower-extremity access in patients…
Impact of Medical Adhesives on Fluid Leakage at Injection Sites Objective The study aimed to see how effective medical glue is in stopping fluid leakage at needle insertion sites in patients with severe swelling. Methods Sixty patients with severe swelling were included in the study from June 2022 to June 2023. They were randomly divided…
Effects of 12-Week Supplementation with Coffee Diterpene Cafestol Study Overview This study looked at how cafestol, a compound found in coffee, affects healthy individuals with a larger waist size who are at risk of type 2 diabetes. Previous research shows coffee may help lower diabetes risk, but the effects of cafestol in humans needed more…
Individualised Computerised Cognitive Training (iCCT) for Mild Cognitive Impairment Overview This study explored the effects of Individualised Computerised Cognitive Training (iCCT) on cognitive abilities in people aged 60+ with Mild Cognitive Impairment (MCI). The iCCT uses machine learning to tailor exercises to each person’s skill level, making training more effective. Study Methods We compared iCCT…
Efficacy of Proinflammatory Cytokines in Pulpotomy Treatments Study Overview This study focused on how different pulpotomy agents affect inflammation levels and treatment success in children. Specifically, it compared levels of IL-6, IL-8, and a new biomarker, presepsin, to assess pulpal inflammation during treatment. Key Findings High Inflammation Levels: Elevated levels of IL-6, IL-8, and presepsin…
Intense Simplified Strategy for Type 2 Diabetes Management Study Overview This study aimed to see if a new treatment approach could help patients newly diagnosed with type 2 diabetes and high blood sugar levels. The approach includes a short period of intensive insulin therapy followed by oral medications. Study Details Design: A multicentre, open label,…
Evaluation of US Elastography in Thyroid Nodule Diagnosis: The ElaTION Randomized Control Trial Background There is mixed evidence regarding the benefits of using US elastography with fine-needle aspiration cytology (FNAC) compared to standard US-guided FNAC for thyroid nodules. Purpose This trial aimed to see if US elastography-guided FNAC could lower the rates of nondiagnostic results…
Impacts of Behavioral Activation on Psychological Distress in Cancer Patients Study Overview This study examined how behavioral activation (BA), a new type of psychological support, can reduce anxiety and psychological distress in patients with esophageal and gastric cancer in China. Methodology 139 patients participated, recruited between March and October 2023. They were randomly divided into…
Evaluating Platelet-Rich Plasma Injection in Spinal Surgery Study Overview This study looks at how effective and safe it is to use platelet-rich plasma (PRP) injections along with a specific spinal surgery known as percutaneous endoscopic nucleotomy for treating lumbar disc herniation (LDH) in younger adults. Study Details Between April 2022 and September 2023, 60 patients…
Study Overview: Targeted Axillary Dissection with Carbon Marking for Breast Cancer Background Neoadjuvant chemotherapy (NAC) can help breast cancer patients with lymph node metastases achieve complete responses, possibly eliminating the need for extensive lymph node removal. Traditional methods for targeted axillary dissection (TAD) using tissue markers have issues like marker loss and high costs. A…
Study Overview This study examines how ketamine and lamotrigine affect brain activity during negative emotional processing. It was conducted as a double-blind, randomized controlled trial using fMRI technology. Key Findings Ketamine’s Role: Ketamine is an effective antidepressant that influences brain circuits related to negative emotions. Lamotrigine’s Impact: Lamotrigine, which reduces glutamate release, can alter the…
Treatment of Post-Stroke Fatigue: A Simple Overview Objective The study aimed to see how a specific acupuncture technique affects fatigue in patients who have had a stroke. Methods Sixty-four patients with post-stroke fatigue were divided into two groups: Control Group: Received standard treatment plus Tongdu Tiaoshen acupuncture therapy. Observation Group: Received the same treatment as…
Acute Cardiovascular Responses of Postmenopausal Women to Resistance Training Sessions Study Overview This study will investigate how different types of resistance training affect cardiovascular health in postmenopausal women. Resistance training is often recommended to help with hormonal changes during menopause, but there are risks associated with intense exercises. This study aims to clarify these effects…
Comprehensive vs. Standard Remote Monitoring of Cardiac Devices in Heart Failure Patients Study Overview The ECOST-CRT study aimed to improve care for heart failure (HF) patients by comparing two types of remote monitoring (RM) for those with cardiac resynchronization therapy (CRT) devices. Study Design Patients were divided into two groups: Control Group: Standard daily RM,…