The Role of Trimethoprim/Sulfamethoxazole in Preventing Infections in SLE Patients Study Overview This study focused on patients with systemic lupus erythematosus (SLE) who are at risk for infections while receiving low-level immunosuppressive treatment. The goal was to see if trimethoprim/sulfamethoxazole (TMP/SMX) could help prevent these infections. Methodology The trial was conducted at Ramathibodi Hospital from…
Improving Antibiotic Prescribing for Older Adults: Key Findings from the ImpresU Study Background We conducted a study in Poland, the Netherlands, Norway, and Sweden to address antibiotic use for urinary tract infections (UTIs) in frail older adults. Our intervention significantly decreased antibiotic prescriptions compared to standard care. Methods We evaluated our intervention, which included a…
A Study on E-Learning for TMJ Examination in Juvenile Idiopathic Arthritis Background This study aimed to assess how effective an e-learning module is for teaching the physical examination of the temporomandibular joint (TMJ) in children with Juvenile Idiopathic Arthritis (JIA). Methods Researchers created an e-learning module focusing on best practices for TMJ examination. Pediatric rheumatology…
TELESCOPE Intervention Overview Study Focus The TELESCOPE intervention aims to improve shared decision-making (SDM) for lung cancer screening (LCS) through telehealth support by patient navigators. This is particularly important as LCS can lower lung cancer death rates but also poses some risks to patients. The Centers for Medicare & Medicaid Services (CMS) requires SDM discussions…
Home-Based Breathing and Chest Mobility Exercise for Long COVID Study Overview This study investigates how home-based breathing and chest mobility exercises can help improve physical fitness in patients with long COVID who also have heart-related issues. Key Findings Participants: 46 patients with long COVID and cardiovascular problems. Method: Patients were divided into two groups: one…
Effect of Weight-Maintaining Ketogenic Diet on Diabetes Management Study Overview A recent study published in BMJ Open Diabetes Research & Care explored the impact of low carbohydrate ketogenic diets on people with obesity and type 2 diabetes (T2D). These diets aim to help with weight loss, better blood sugar control, and lower insulin resistance. Research…
Clinical Development of AdVEGF-D Therapy for Refractory Angina Background Many patients with coronary artery disease still experience severe chest pain, known as refractory angina, despite existing treatments. A new gene therapy called AdVEGF-D has the potential to help these patients. About the ReGenHeart Trial The ReGenHeart trial is a phase 2 study designed to test…
Establishing a Risk Model for Diabetic Nephropathy Introduction This study aims to create a model that predicts the risk of diabetic nephropathy (DN) in patients with type 2 diabetes. It also examines the effects of combining Epalrestat with Dapagliflozin for treating DN. Methods The study had two phases: Phase I: Analyzed data from 460 patients…
Adherence to a Low-Fat Diet Lowers Head and Neck Cancer Risk Study Overview The study focused on how a low-fat dietary pattern (LFD) affects the risk of head and neck cancer (HNC). A low-fat diet means eating less fat overall. Study Methods The research used data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer…
Effects of Inhaled Beclometasone Dipropionate/Formoterol Fumarate/Glycopyrronium in COPD Study Overview This study investigated the effects of a single inhaler containing beclometasone dipropionate, formoterol fumarate, and glycopyrronium (BDP/FF/G) on lung hyperinflation and exercise endurance in patients with chronic obstructive pulmonary disease (COPD). Key Findings Participants: 106 adults with COPD were enrolled; 95 completed the study. Improvement…
Participant Motivators and Expectations in the MEL-SELF Clinical Trial Background There is limited information about why patients join dermatology clinical trials, especially for melanoma. Understanding what motivates participants is crucial for improving trial methods. Objective This study aimed to discover what motivates patients to participate in the MEL-SELF trial, which focuses on patient-led monitoring for…
Is a Tourniquet Necessary for ACL Reconstruction? A Study Overview Purpose of the Study This study looked at whether using a tourniquet during arthroscopic anterior cruciate ligament (ACL) reconstruction is beneficial. We focused on: Intraoperative visualization Surgical time Use of sterile saline Postoperative pain Study Methodology In this clinical trial, patients were split into two…
Paternal HLA-Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss: New Insights From a Clinical Trial Overview of Recurrent Pregnancy Loss (RPL) Recurrent pregnancy loss (RPL) is when a woman has two or more miscarriages before the 24th week of pregnancy. This condition affects 1%-3% of women globally. About 40% of RPL cases are…
EYE-ECG Study Overview This study examined how expert eye-tracking videos can help medical students improve their ECG interpretation skills. Objectives Teaching ECG interpretation often uses visual aids, but students usually struggle with it. This study aimed to show how an expert’s gaze can be made visible through eye-tracking videos, potentially enhancing students’ skills. Methods A…
ANODYNE Study Overview This study investigates the effectiveness of greater occipital nerve block (GONB) using methylprednisolone and lignocaine for preventing episodic cluster headaches. Background There is limited evidence on how well GONB works for treating cluster headaches. This study aimed to evaluate its effectiveness and safety as a transitional preventive treatment. Methods Conducted in New…
Prognostic Impact of Admission Time in Infarct-Related Cardiogenic Shock Study Overview This study looks at how the timing of hospital admission affects patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS) and the effectiveness of extracorporeal life support (ECLS). Key Objectives The goal was to compare outcomes for patients admitted during regular hours (on-hours)…
N-acetylcysteine Supplementation for PCOS Study Overview Polycystic ovary syndrome (PCOS) affects 6-20% of women globally. Many women with PCOS experience insulin resistance and high insulin levels, which worsen oxidative stress and contribute to the condition. N-acetylcysteine (NAC) is an antioxidant that may help treat PCOS. This study looked at how NAC affects metabolic health in…
The Impact of Synbiotics on Drug-Resistant Epilepsy and Caregiver Stress Study Overview This study explored how synbiotics can help children with drug-resistant epilepsy (DRE) and ease the stress on their caregivers. Synbiotics are a mix of probiotics and prebiotics that support gut health. Study Details Conducted in Arak, Iran with 30 children diagnosed with DRE.…
Implementing a Remote Self-Screening Program for Atrial Fibrillation Overview This study evaluates how feasible it is to use digital health technology for self-screening of atrial fibrillation (AF) in older adults living in the community, specifically those aged 75 and older. Study Design The research involved a process evaluation of the Mass AF clinical trial, using…
Nivolumab+AVD in Advanced-Stage Classic Hodgkin’s Lymphoma Study Overview This study compares two treatments for advanced-stage classic Hodgkin’s lymphoma: Brentuximab vedotin combined with AVD (BV+AVD) Nivolumab combined with AVD (N+AVD) Brentuximab can improve outcomes but may lead to more side effects and challenges with relapses. Nivolumab has shown effectiveness, especially in previously untreated patients. Trial Details…