Effect evaluation of outpatient long-term video EEGs for people with seizure disorders — study protocol of the ALVEEG project: a randomized controlled trial in Germany ABSTRACT Epilepsy and other seizure disorders have a significant impact in Germany. Timely diagnosis and accurate treatment are crucial, and the management of these disorders needs improvement. Outpatient long-term video…
Impact of Intervention Package on Antibiotic Prescriptions for Acute Febrile Illness Study Overview An intervention package including point-of-care diagnostic tests, a clinical algorithm, and adherence training was implemented in primary health facilities in Burkina Faso during the COVID-19 pandemic. The study aimed to assess the impact of this package on antibiotic prescriptions and clinical recovery…
MRI Tumor Regression Response to Neoadjuvant Chemotherapy Alone without Radiation for Rectal Adenocarcinoma Summary This study investigated the accuracy of MRI in assessing pathologic complete response in patients with locally advanced rectal cancer (LARC) who underwent surgery after neoadjuvant chemotherapy (NCT) without radiation. The results show that MRI-based models were accurate for determining pathologic complete…
Management of the Axilla After Neoadjuvant Chemotherapy: Can Axillary Needle Biopsy Replace Sentinel Node Biopsy? Background The study aimed to determine if axillary needle biopsy could effectively evaluate the axilla after treatment in breast cancer patients who had received neoadjuvant chemotherapy (NAC) without the need for sentinel lymph node biopsy (SLNB). Patients and Methods The…
Evaluation of the Impact of an Online Video Game as an Educational Intervention on Sexual Health and the Prevention, Diagnosis, and Treatment of Sexually Transmitted Infection: A Randomized Controlled Trial Protocol Background The incidence of sexually transmitted infections (STIs) is increasing, especially among young people. There is a need for tools to improve knowledge about…
Impact of Telemonitoring on Multiple Myeloma Patients Practical Solutions and Value Multiple myeloma (MM) is a serious condition with significant impact on patients’ lives. To address the challenges of complex treatment regimens, the MM e-coach telemonitoring tool was developed and tested. This study aims to assess the impact of telemonitoring on medication adherence, complications, and…
Lay-Led Intervention for War and Refugee Trauma: A Randomized Clinical Trial Importance The global refugee crisis disproportionately affects the Muslim world, leading to trauma-related mental health issues. Effective psychotherapy exists, but barriers to uptake by refugee groups and lack of culturally appropriate interventions remain. Objective To examine the efficacy of a brief, lay-led, mosque-based intervention,…
Pentoxifylline Reduces Subclinical Atherosclerosis in Patients with Type 2 Diabetes and Chronic Kidney Disease Key Findings: Pentoxifylline (PTF) shows positive effects on the progression of subclinical atherosclerosis (SA) in patients with type 2 diabetes mellitus and chronic kidney disease (CKD). Practical Solutions: PTF treatment resulted in improved carotid intima-media thickness (CIMT), increased levels of the…
Study Title The effects of combining remimazolam with estazolam on postoperative hemodynamics and pain intensity in patients undergoing laparoscopic gastrointestinal surgery Published in BMC Surgery, August 24, 2024 PMID: 39182049 | DOI: 10.1186/s12893-024-02527-8 Objective This study aimed to investigate the effects of combining remimazolam with estazolam on hemodynamics and pain levels after laparoscopic gastrointestinal surgery.…
Community-Engaged Trial to Increase COVID-19 Vaccine Uptake in Black Individuals with Rheumatic Conditions Published in BMJ Open, August 24, 2024 Background: In the US, there are disparities in COVID-19 infection and vaccine uptake among historically marginalized racial and ethnic groups. People with rheumatic conditions, especially those who are immunocompromised, are at higher risk for severe…
Interim Analysis of Beta-blocker Use in Traumatic Brain Injury Key Highlights This interim analysis explores the impact of early administration of beta-blockers on adrenergic surge, pro-inflammatory cytokines, and traumatic brain injury (TBI) biomarkers. Patients with positive high-sensitivity troponin T (HsTnT) levels received propranolol, while those with negative test were randomized to receive propranolol or placebo.…
Kinetic Profiling of RAS Mutations in Metastatic Colorectal Cancer Study Overview Researchers tracked RAS mutation status in metastatic colorectal cancer patients over time using circulating tumor DNA (ctDNA) sequencing during the CO.26 trial, which assessed durvalumab + tremelimumab treatment in heavily pretreated patients. Key Findings Among the patients with RAS mutations, a small percentage (3.2%-6.3%)…
Shared Decision-Making in Colorectal Cancer Screening for Older Adults: A Secondary Analysis of a Cluster Randomized Clinical Trial Summary Deciding whether to stop colorectal cancer (CRC) screening tests in older adults can be challenging. This study evaluated the impact of physician training in shared decision-making (SDM) and electronic previsit reminders on the receipt of patient-preferred…
Characterizing HIV Drug Resistance in Vertical Transmission Cases Study Overview The VESTED trial compared the safety and effectiveness of three different antiretroviral treatment regimens in pregnant and postpartum women with HIV. The study aimed to evaluate the occurrence of vertical HIV transmission (VT) in infants born to these women and to assess HIV drug resistance…
Enhancing Positive Adaptation of Immigrant Families in Hong Kong: Clinical Trial Results Overview Our research team conducted a randomized controlled trial to enhance positive adaptation among immigrant parents and children in Hong Kong. We developed two parallel interventions aiming to address psychological and sociocultural adaptation difficulties faced by immigrant families. Interventions Two interventions were conducted:…
Streamlined Genetic Education and Cascade Testing in Hereditary Cancer Families: Key Findings Introduction When a pathogenic BRCA1 or BRCA2 mutation is found in a family, it is important for family members to undergo cascade genetic testing to guide screening and treatment decisions. However, men are less likely than women to pursue cascade testing. To address…
Study Title: A gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma Nature Communications, August 21, 2024 Key Findings: Malignant mesothelioma, a rare cancer linked to asbestos exposure, has limited treatment options and poor prognosis. A multi-center phase II clinical trial (MiST4, NCT03654833) evaluated atezolizumab and bevacizumab (AtzBev) in relapsed mesothelioma patients,…
HSD3B1 Genotype and Outcomes in Metastatic Prostate Cancer Practical Solutions and Value Highlights HSD3B1 genotype plays a role in metastatic hormone-sensitive prostate cancer (mHSPC) outcomes. The AP allele is linked to castration resistance, particularly in low-volume tumors, affecting post-progression mortality and treatment-emergent adverse events. Enzalutamide plus androgen deprivation therapy (ADT) in men with mHSPC showed…
Effect of Narrative Photography on Physical Therapy Students’ Learning Outcomes in Heart Transplantation Nursing and Health Sciences, September 2024, Volume 26, Issue 3, Article e13155 Physical therapy students need to understand how to care for patients undergoing heart transplantation, including their emotional and practical needs. This study compared the effectiveness of a narrative photography (NP)…
Comparison of Two Symptom Checkers (Ada and Symptoma) in the Emergency Department: Randomized, Crossover, Head-to-Head, Double-Blinded Study ABSTRACT Emergency departments (EDs) are often overcrowded, and nonurgent patients frequently seek care there. Symptom checkers (SCs) provide immediate access to disease suggestions and recommended actions, potentially improving patient flow. However, there is a lack of evidence supporting…