Adoption of Cardiopulmonary Exercise Testing in Rehabilitation of Coronary Artery Disease Patients BMC Cardiovasc Disord. 2024 Jun 21;24(1):313 Summary: This study explored the use of cardiopulmonary exercise testing in patients with coronary artery disease (CAD) and its impact on exercise ability and cardiopulmonary function. Significant improvements in health outcomes and quality of life were observed.…
Precision Medicine to Redefine Insulin Secretion and Monogenic Diabetes-Randomized Controlled Trial (PRISM-RCT) Highlights of the Study We designed a patient-centered care model to evaluate its impact on clinical outcomes in young-onset type 2 diabetes patients. Research Design and Methods The trial evaluates a multicomponent care model using technology, biogenetic markers, and patient-reported outcomes in patients…
miR-221-3p: A Potential Biomarker for Chronic Periodontitis Overview Researchers investigated the role of miR-221-3p in chronic periodontitis (CP) development and management. They aimed to uncover its diagnostic potential and therapeutic implications. Key Findings miR-221-3p levels were lower in CP patients compared to healthy individuals. miR-221-3p demonstrated high diagnostic accuracy for CP, showing potential as a…
The Effect of Tub Bathing on Newborns Undergoing Phototherapy: A Clinical Trial Objective To study the impact of tub bathing on the skin and bilirubin levels of newborns undergoing tunnel and light-emitting diode phototherapy. Methods Newborns with hyperbilirubinemia receiving tunnel or light-emitting diode phototherapy were randomly assigned to either a bath or no bath group.…
Randomised, Split-Face Study of Dermocosmetic Cream for Rosacea Published in Skin Research and Technology, June 2024 Objective: To assess the benefit of a dermocosmetic cream (DC cream) containing Sphingobioma xenophaga extract and soothing agent in adult females with rosacea-associated erythema and sensitive skin. Methods: The study involved a 28-day phase where DC was applied twice…
The effect of educational intervention based on health belief model on colorectal cancer screening behaviors BMC Public Health. 2024 Jun 19;24(1):1640. doi: 10.1186/s12889-024-19180-8. Summary: This study aimed to assess the impact of an educational intervention based on the health belief model (HBM) on colorectal cancer screening behaviors in individuals aged 50 and above. Methods: 134…
Web-Based, Human-Guided, or Computer-Guided Transdiagnostic Cognitive Behavioral Therapy in University Students With Anxiety and Depression: Randomized Controlled Trial Key Findings: Web-based interventions were marginally more effective than usual care over 6 months. All groups showed significant improvement in depression and anxiety symptoms over time. Participants in the human-guided condition attended more sessions than those in…
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Effect of a Dietary Supplement Containing Dry Artichoke and Bergamot Extracts on Metabolic and Vascular Risk Factors in Individuals with Suboptimal Cholesterol Levels Key Findings The study found that a dietary supplement containing dry extracts of bergamot and artichoke significantly improved serum lipid concentration and insulin sensitivity,…
Efficacy and Mechanisms of TCPS Qigong for Insomnia in College Students Protocol for a Double-Blind, Randomized Controlled Trial Background: Insomnia in college students is often overlooked despite its impact on health and wellbeing. Improving sleep quality through targeted interventions can reduce the risk of related health issues. Qigong exercises, specifically Three-circle Post Standing (TCPS), have…
Efficacy and Safety of Eliapixant in Endometriosis-Associated Pelvic Pain: The SCHUMANN Study Published in BMC Women’s Health, June 19, 2024 Background: The SCHUMANN study assessed the effectiveness and safety of eliapixant in treating endometriosis-associated pelvic pain (EAPP). Methods: This was a phase 2b study involving women with surgically diagnosed endometriosis and EAPP. Participants were randomly…
Functioning and Quality of Life Among Adults with Psychotic Disorders in Tanzania: KUPAA Clinical Trial Key Findings and Implications Understanding the functioning and quality of life of individuals with psychotic disorders is essential for informing policies and programs in low-resource settings like urban Tanzania. Results from the KUPAA clinical trial revealed that higher disability was…
Microvascular Recovery with Ultrasound in Myocardial Infarction Post-PCI Trial Abstract Purpose: This study aimed to assess the effectiveness of post-PCI sonothrombolysis in patients with acute anterior wall STEMI. Methods: A randomized controlled trial was conducted on 50 patients who underwent continuous microbubble infusion following successful PCI. Sonothrombolysis was applied in the treatment group. MRI was…
Efficacy and Neural Mechanisms of Mindfulness Meditation Among Adults With Internet Gaming Disorder: A Randomized Clinical Trial Overview The study aimed to assess the effectiveness of mindfulness meditation (MM) in treating internet gaming disorder (IGD) and to identify the neural mechanisms behind MM treatment. Key Findings MM was more effective than progressive muscle relaxation (PMR)…
Comparative Effectiveness of Personal Sound Amplification Products Versus Hearing Aids for Unilateral Hearing Loss: A Prospective Randomized Crossover Trial ABSTRACT This study compared the effectiveness of personal sound amplification products (PSAPs) and hearing aids (HAs) for individuals with moderate to moderately severe unilateral hearing loss. Thirty-nine participants were randomly assigned to use either a basic…
Cost-effectiveness of Talazoparib for Advanced Breast Cancer Key Findings: Talazoparib, a targeted PARP inhibitor, has shown significant extension in progression-free survival and improved response markers for patients with germline BRCA1/2 mutated HER2-negative advanced breast cancer, compared to conventional therapies. Practical Solutions: Our analysis aims to assess the cost-effectiveness of talazoparib in treating advanced breast cancer…
Lateral Episiotomy in Vacuum Assisted Delivery for First-Time Mothers Objective To compare the effect of lateral episiotomy versus no episiotomy on obstetric anal sphincter injury in first-time mothers requiring vacuum extraction. Study Design A multicentre, open label, randomised controlled trial conducted in eight hospitals in Sweden from 2017 to 2023. Participants 717 first-time mothers with…
Assessing the Impact of Jail-Initiated Medication for Opioid Use Disorder: A Multisite Analysis of the SOMATICS Collaborative Objective The objective of this study was to assess the effects of jail-initiated medication for opioid use disorder (MOUD) and patient navigation (PN) on opioid use disorder (OUD) at 6 months post-release. Study Details Three randomized trials (combined…
Cost-Effectiveness Analysis of Bevacizumab Combined with Lomustine in the Treatment of Progressive Glioblastoma Key Findings Compared to Lomustine alone, the combination of Bevacizumab and Lomustine increased the total treatment cost from $2,646.70 to $23,650.98. The health-adjusted life years (QALYs) for the combination therapy increased from 0.26 QALYs to 0.51 QALYs, representing an increment of 0.25…
Characterization of Anti-Drug Antibody Responses to Cibisatamab Practical Solutions and Value An appropriately designed pharmacokinetic (PK) assay sensitive for anti-drug antibody (ADA) impact on exposure is an alternative strategy to understand the neutralizing potential of ADAs. The PK assay of cibisatamab, a T-cell-engaging bispecific antibody, was developed based on its mechanism of action (MoA). Using…
Short-term effects of gastric bypass versus sleeve gastrectomy on high LDL cholesterol: The BASALTO randomized clinical trial ABSTRACT There has been a substantial increase in the use of laparoscopic sleeve gastrectomy (SG) to treat morbid obesity despite observational evidence demonstrating the superiority of Roux-en-Y gastric bypass (RYGB) for reducing low-density lipoprotein (LDL) cholesterol. The main…