Public Health Overview Study Title: Early Dementia Diagnosis in Cuba Reference: Alzheimers Dement. 2024 Dec;20 Suppl 7:e086012. doi: 10.1002/alz.086012 Background A large number of the 57 million people with dementia live in low- and middle-income countries, where research on dementia is limited. Our goal was to improve early diagnosis and the use of standard cognitive…
Public Health Study Overview This study analyzed the cost-effectiveness of the Japanese multimodal intervention trial for dementia prevention (J-MINT) from a societal viewpoint. Methodology We used a Markov model to assess the economic impact of the J-MINT trial, which included participants aged 65 to 85 with mild cognitive impairment. Participants were divided into two groups:…
Public Health Overview Background Research shows that sex and gender influence Alzheimer’s and Dementia differently. Women are often diagnosed later than men, which poses challenges for healthcare and clinical trials due to potential gender biases in participant selection. About the CITA GO-ON Trial The CITA GO-ON study (ClinicalTrials.gov, NCT04840030) is a randomized clinical trial designed…
Public Health Study Overview This study looks at the healthcare needs of people living with dementia (PlwD), especially those with Alzheimer’s disease. Many needs are not being met, and we aim to understand the factors that influence these unmet needs to create better support systems. Methodology We analyzed data from a multi-centre clinical trial called…
Public Health Study Overview The IPAT trial is a study aimed at preventing Alzheimer’s disease by examining how lowering high systolic blood pressure (SBP) affects brain health in older adults. This study will last for 2 years and is currently recruiting participants. Key Details Study Duration: October 2022 – September 2025 Participants Needed: 180 individuals…
Public Health Update on Cognitive Decline Interventions Background Multidomain lifestyle changes may help slow down cognitive decline and prevent dementia. The U.S. POINTER trial is a significant study looking at how these lifestyle changes affect older adults at risk of cognitive issues. Methods We created four scores to measure how well participants engaged in the…
Drug Development Overview Background Abnormal glucose metabolism in Alzheimer’s Disease (AD) is linked to cognitive issues. This is similar to what happens with a lack of thiamine (vitamin B1) in the brain. In animal studies, thiamine deficiency leads to memory loss, neuron damage, brain inflammation, and other AD-like symptoms. Increasing thiamine levels significantly using benfotiamine…
Drug Development Overview Background Patients with Alzheimer’s disease (AD) often face challenging neuropsychiatric symptoms, like agitation. This can lead to increased stress for caregivers and more placements in long-term care facilities. AXS-05, a new drug combining dextromethorphan and bupropion, is being studied for treating AD agitation (ADA). It is already FDA-approved for major depressive disorder.…
Drug Development LatAm-FINGERS Trial Overview The LatAm-FINGERS trial is a groundbreaking clinical study involving participants from 12 Latin American countries. This trial focuses on providing inclusive and diverse recruitment, especially for underserved populations. Methodology This trial is a multicenter randomized study that assesses a lifestyle intervention designed for the Latin American community. Key features include:…
Drug Development in Alzheimer’s Disease Trials Background In Alzheimer’s Disease (AD) trials, we use clinical scales to measure how well treatments work. To improve the accuracy of trial results, we can use machine learning to create AI-generated digital twins. These digital twins give us personalized predictions of how a patient’s condition might change if they…
Drug Development Study Overview This clinical trial examined the use of transcutaneous vagus nerve stimulation (tVNS) to help improve memory and cognitive function in participants with mild cognitive impairment (MCI). Trial Details The study had a randomized, double-blind, placebo-controlled crossover design. A total of 59 participants with MCI were divided into two groups: one received…
Drug Development Study Overview The study titled “Acute Exercise Response on Brain Imaging and Cognition (AEROBIC)” investigates how aerobic exercise affects brain health in older adults. It includes both cognitively healthy and impaired individuals aged 60 and above. Key Findings Exercise Benefits: Aerobic exercise significantly improves brain metabolism, as shown by changes in glucose levels…
Dementia Care Research and Psychosocial Factors Study Overview This study, published in Alzheimers Dement, focuses on improving dementia awareness and reducing stigma among healthcare workers and the public. Background Many people lack knowledge about dementia, leading to stigma and discrimination. To combat this, we need effective interventions that are based on evidence. Methodology We conducted…
Technology and Dementia Preconference Background Alzheimer’s disease (AD) is a major global health issue that requires new treatment methods. Recent advancements in medical devices using biophoton technology have shown promise in enhancing the cognitive abilities and quality of life for AD patients. Method This study was a randomized, triple-blinded, placebo-controlled clinical trial aimed at determining…
The Newborn Behaviour Observation (NBO) System: A Study in Iceland Study Overview The Newborn Behaviour Observation system (NBO) is a helpful tool for parents to understand their newborns better. This study aimed to see how this system affects mothers’ confidence in the first month after giving birth and the quality of interactions between mothers and…
The Impact of Hand and Foot Exercises on Women with Breast Cancer Study Overview This study investigates how hand and foot exercises influence peripheral neuropathy and overall quality of life in women undergoing chemotherapy for breast cancer. Importance of the Study Peripheral neuropathy can greatly affect patients’ lives. This research aims to identify supportive care…
Study on At-Home Teeth Bleaching with 10% Carbamide Peroxide Background This study tested if using 10% carbamide peroxide (CP) for 2 or 4 hours daily is as effective as using it for 8 hours daily. Methods A total of 120 healthy adults with teeth shades A2 or darker participated. They were divided into three groups…
Testing the Heart Failure Activity Coach Study (HEALTHY) Background Heart failure (HF) is a serious condition linked to a lack of physical activity. While many patients survive their first year after diagnosis, being inactive can lead to higher mortality rates and lower quality of life. Objective This study aimed to evaluate how well we could…
Understanding Patient Experiences with Eosinophilic Esophagitis (EoE) Purpose of the Study Eosinophilic esophagitis (EoE) is a long-term immune-related disease that causes symptoms like: Difficulty swallowing (dysphagia) Food getting stuck Abdominal pain Vomiting Heartburn This condition can significantly lower quality of life due to its physical and emotional effects. This study aimed to gather insights from…
Acute Hypoalgesic and Neurophysiological Responses to Lower-Limb Ischaemic Preconditioning Study Overview This study aimed to find out if ischaemic preconditioning (IPC) can help reduce pain and improve muscle response during voluntary movements. Healthy participants took part in three sessions after getting familiar with the procedures. Key Findings Pain Threshold Improvement: After IPC, the pressure pain…