Intranasal Oxytocin for Apathy in Frontotemporal Dementia (FOXY)
Study Overview
This study tested intranasal oxytocin as a treatment for apathy in people with frontotemporal dementia. Currently, there are no effective treatments for this condition.
Key Findings
- Oxytocin was given every third day and showed a small improvement in apathy scores.
- Out of 94 participants, 40% were female and 60% were male, with an average age of 65.9 years.
- Two common side effects were reported: upper respiratory infections and headaches, but none were linked directly to oxytocin treatment.
Study Design
The trial was conducted across 11 clinics in Canada and the USA, involving:
- Participants aged 30-80 with probable frontotemporal dementia.
- A random assignment to receive either oxytocin or a placebo.
- Each treatment lasted 6 weeks, followed by a washout period before switching treatments.
Practical Solutions and Value
This research highlights the potential of oxytocin as a treatment option for apathy in frontotemporal dementia. Future studies may explore stronger formulations and different dosing schedules to enhance effectiveness.
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