Evaluating a Digital Tool for Breast Cancer Support: The ADAPT Study Purpose: This study examines how a digital tool aids self-management for individuals affected by breast cancer. It focuses on patient activation as the main goal, while also looking at health-related quality of life (HRQoL) and overall health status as secondary goals. Methods: Women with…
Pelvic Binder Radiography: A Safe Method for Assessing Pelvic Fractures Study Overview This clinical trial aimed to evaluate the safety and effectiveness of using a pelvic binder (PBR) to measure fracture stability in patients with lateral compression type 1 (LC1) pelvic fractures. Key Objectives To assess fracture displacement. To evaluate patient comfort during the procedure.…
Revefenacin Area Under the Curve Spirometry in Patients with Moderate to Very Severe COPD Study Overview This study focuses on the effectiveness of Revefenacin, a once-daily bronchodilator, in improving lung function in patients with chronic obstructive pulmonary disease (COPD). It highlights the importance of measuring lung function through various endpoints, including the area under the…
Reducing Rehospitalization in Cardiac Patients A Study on Cardiac Care Management Program in Germany Background: This study tested a new care management program that provides support to heart patients after they leave the hospital. We compared this program to standard care to see which was more effective. Methods: The study started in 2019/2020 and involved…
Study Overview of CHF6523 in COPD Management Background Chronic obstructive pulmonary disease (COPD) is a long-term inflammatory condition. Many patients still suffer from flare-ups, indicating a need for new anti-inflammatory treatments. Researchers have focused on a specific enzyme, phosphoinositide 3-kinase delta (PI3Kδ), to see if targeting it could help manage inflammation in COPD. What Was…
Study Overview This study investigates the impact of inaudible infrasound exposure on brain function and behavior, focusing on changes in brain connectivity. Key Findings 38 participants were exposed to inaudible infrasound for four weeks. Changes in brain connectivity were observed in various networks: Decreased connectivity in the right precuneus (part of the default mode network).…
The Role of Trimethoprim/Sulfamethoxazole in Preventing Infections in SLE Patients Study Overview This study focused on patients with systemic lupus erythematosus (SLE) who are at risk for infections while receiving low-level immunosuppressive treatment. The goal was to see if trimethoprim/sulfamethoxazole (TMP/SMX) could help prevent these infections. Methodology The trial was conducted at Ramathibodi Hospital from…
Improving Antibiotic Prescribing for Older Adults: Key Findings from the ImpresU Study Background We conducted a study in Poland, the Netherlands, Norway, and Sweden to address antibiotic use for urinary tract infections (UTIs) in frail older adults. Our intervention significantly decreased antibiotic prescriptions compared to standard care. Methods We evaluated our intervention, which included a…
A Study on E-Learning for TMJ Examination in Juvenile Idiopathic Arthritis Background This study aimed to assess how effective an e-learning module is for teaching the physical examination of the temporomandibular joint (TMJ) in children with Juvenile Idiopathic Arthritis (JIA). Methods Researchers created an e-learning module focusing on best practices for TMJ examination. Pediatric rheumatology…
TELESCOPE Intervention Overview Study Focus The TELESCOPE intervention aims to improve shared decision-making (SDM) for lung cancer screening (LCS) through telehealth support by patient navigators. This is particularly important as LCS can lower lung cancer death rates but also poses some risks to patients. The Centers for Medicare & Medicaid Services (CMS) requires SDM discussions…
Home-Based Breathing and Chest Mobility Exercise for Long COVID Study Overview This study investigates how home-based breathing and chest mobility exercises can help improve physical fitness in patients with long COVID who also have heart-related issues. Key Findings Participants: 46 patients with long COVID and cardiovascular problems. Method: Patients were divided into two groups: one…
Effect of Weight-Maintaining Ketogenic Diet on Diabetes Management Study Overview A recent study published in BMJ Open Diabetes Research & Care explored the impact of low carbohydrate ketogenic diets on people with obesity and type 2 diabetes (T2D). These diets aim to help with weight loss, better blood sugar control, and lower insulin resistance. Research…
Clinical Development of AdVEGF-D Therapy for Refractory Angina Background Many patients with coronary artery disease still experience severe chest pain, known as refractory angina, despite existing treatments. A new gene therapy called AdVEGF-D has the potential to help these patients. About the ReGenHeart Trial The ReGenHeart trial is a phase 2 study designed to test…
Establishing a Risk Model for Diabetic Nephropathy Introduction This study aims to create a model that predicts the risk of diabetic nephropathy (DN) in patients with type 2 diabetes. It also examines the effects of combining Epalrestat with Dapagliflozin for treating DN. Methods The study had two phases: Phase I: Analyzed data from 460 patients…
Adherence to a Low-Fat Diet Lowers Head and Neck Cancer Risk Study Overview The study focused on how a low-fat dietary pattern (LFD) affects the risk of head and neck cancer (HNC). A low-fat diet means eating less fat overall. Study Methods The research used data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer…
Effects of Inhaled Beclometasone Dipropionate/Formoterol Fumarate/Glycopyrronium in COPD Study Overview This study investigated the effects of a single inhaler containing beclometasone dipropionate, formoterol fumarate, and glycopyrronium (BDP/FF/G) on lung hyperinflation and exercise endurance in patients with chronic obstructive pulmonary disease (COPD). Key Findings Participants: 106 adults with COPD were enrolled; 95 completed the study. Improvement…
Participant Motivators and Expectations in the MEL-SELF Clinical Trial Background There is limited information about why patients join dermatology clinical trials, especially for melanoma. Understanding what motivates participants is crucial for improving trial methods. Objective This study aimed to discover what motivates patients to participate in the MEL-SELF trial, which focuses on patient-led monitoring for…
Is a Tourniquet Necessary for ACL Reconstruction? A Study Overview Purpose of the Study This study looked at whether using a tourniquet during arthroscopic anterior cruciate ligament (ACL) reconstruction is beneficial. We focused on: Intraoperative visualization Surgical time Use of sterile saline Postoperative pain Study Methodology In this clinical trial, patients were split into two…
Paternal HLA-Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss: New Insights From a Clinical Trial Overview of Recurrent Pregnancy Loss (RPL) Recurrent pregnancy loss (RPL) is when a woman has two or more miscarriages before the 24th week of pregnancy. This condition affects 1%-3% of women globally. About 40% of RPL cases are…
EYE-ECG Study Overview This study examined how expert eye-tracking videos can help medical students improve their ECG interpretation skills. Objectives Teaching ECG interpretation often uses visual aids, but students usually struggle with it. This study aimed to show how an expert’s gaze can be made visible through eye-tracking videos, potentially enhancing students’ skills. Methods A…