Effects of Rehabilitative Exercise and Neuromuscular Electrical Stimulation on Muscle Morphology and Dynamic Balance in Individuals with Chronic Ankle Instability Summary Muscle atrophy due to chronic ankle instability (CAI) can lead to muscle weakness, altered movement patterns, and increased injury risk. This study investigated the effects of rehabilitative exercises and neuromuscular electrical stimulation (NMES) on…
Study of Two Sedative Protocols for Drug-Induced Sleep Endoscopy Practical Solutions and Value Obstructive sleep apnea (OSA) is a common condition with serious health impacts. While CPAP is the standard treatment, some patients cannot tolerate it. Drug-induced sleep endoscopy (DISE) helps evaluate airway obstruction and plan surgical treatment. Our study compared two sedation protocols for…
Effect of Diaphragmatic Breathing Exercises on Mental Fatigue and Upper Extremity Functions Key Findings This study explored the impact of mental fatigue induced by motor imagery on upper limb function. It found that mental fatigue can lead to decreased elbow flexion strength, hand grip strength, and upper extremity endurance, while also increasing tactile sensitivity. Intervention…
Aquatic Exercise and Type 2 Diabetes Study Overview A recent clinical trial compared the effects of aquatic and dry-land walking/running on blood glucose and plasma renin activity (PRA) in individuals with type 2 diabetes. The study found that both aquatic and dry-land sessions led to reductions in blood glucose levels, while only the aquatic session…
Study Title: Hippocampal Avoidance Whole-Brain Radiotherapy for Lung Cancer Brain Metastases Summary This study evaluated the effectiveness of a specific radiotherapy technique and cognitive testing in Chinese lung cancer patients with brain metastases. The results showed promising outcomes in terms of survival and cognitive function. Key Findings – The median survival for all patients was…
Study on Whitening Efficacy and Tooth Sensitivity of Hydrogen Peroxide Overview This study compared the effectiveness of using different concentrations of hydrogen peroxide gels with violet or blue LED light for teeth whitening and evaluated tooth sensitivity. Results Groups using higher concentration hydrogen peroxide with violet or blue LED showed better whitening results compared to…
Safety and Efficacy of High-Dose Inhaled Nitric Oxide for COVID-19 Viral Pneumonia Key Findings: • Intermittent 150-ppm iNO-treatment is well-tolerated, safe, and beneficial compared to usual care for spontaneously breathing hospitalised adults diagnosed with COVID-19 viral pneumonia. • Oxygen support duration was reduced by 2.7 days, a greater number of subjects reached oxygen saturation ≥…
Feasibility of Home-Based Testing for Acute Respiratory Viruses Key Findings: DETECT-AHEAD trial showed early feasibility of a decentralized program to prompt individuals to use a viral pathogen diagnostic test based on symptoms tracked in the study app or physiological changes detected using a wearable sensor. Practical Solutions: Our study demonstrated the potential for home-based diagnostic…
Phase 2 Study of NE3107 in Patients with Dementias Key Findings and Practical Solutions NE3107, an oral, anti-inflammatory, insulin-sensitizing molecule, showed positive effects in patients with mild cognitive impairment or mild dementia. Practical Solutions: NE3107 was associated with improvements in cerebral blood flow and brain functional connectivity. Patients showed improvements in cognitive assessments, including ADAS-Cog11,…
ER-Targeted PET for Initial Staging and Suspected Recurrence in ER-Positive Breast Cancer JAMA Netw Open. 2024 Jul 1;7(7):e2423435. doi: 10.1001/jamanetworkopen.2024.23435. Objective: To compare the detection rate of 16α-18F-fluoro-17β-estradiol (FES) positron emission tomography (PET) computed tomography (CT) with standard-of-care imaging (SOC) for staging locally advanced breast cancer (LABC) or evaluating suspected recurrence in ER-positive breast cancer.…
Factors predicting long-term outcomes following physiotherapy in patients with subacromial pain syndrome: a secondary analysis ABSTRACT Patients with shoulder complaints often undergo physiotherapy, but it’s unclear which factors predict long-term outcomes. This study aims to identify these factors to help patients make informed treatment decisions, avoid ineffective treatments, and minimize chronic pain risk. AIM This…
Clinical Relevance of Combined Treatment with Exercise in Chronic Low Back Pain Study Summary Chronic low back pain (CLBP) is a common health issue, and this study aimed to evaluate the impact of exercise alone or combined with manual therapy and kinesiotherapy on pain sensitivity, disability, kinesiophobia, self-efficacy, and catastrophizing in CLBP patients. Key Findings…
Study Title: Biomarker-guided Acute Kidney Injury Risk Assessment Highlights of the Study: • Addressed the need for preventative measures against acute kidney injury (AKI) in surgical patients. • Assessed the impact of intraoperative fluid management on AKI in female breast cancer patients undergoing autologous breast reconstruction. • Utilized novel urinary biomarkers (TIMP-2 and IGFBP-7) for…
SomaLogic Proteomics Reveals New Biomarkers in NASH Key Findings from Clinical Trial Non-alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic Steatohepatitis (NASH) are metabolic diseases with no approved therapies. We conducted a Phase 2a trial (NCT03248882) with Clesacostat (PF-05221304), an acetyl coA carboxylase inhibitor (ACCi), in patients with NAFLD/NASH. Our SomaLogic serum proteome profiling identified potential…
Stroke Risk Reduction in Atrial Fibrillation Through Pharmacist Prescribing: A Randomized Clinical Trial Key Findings: Pharmacist-led oral anticoagulation therapy (OAC) prescription significantly increased the delivery of stroke risk reduction therapy in individuals with atrial fibrillation (AF). Guideline-concordant OAC use at 3 months occurred in 92.3% of patients in the early intervention group vs 56.1% in…
Preoperative Promestriene for Hysteroscopy: A Randomized Clinical Trial Objective In hysteroscopy, complications like false passage creation and uterine perforation can lead to procedure suspension, causing delays in diagnosing uterine pathology. This study aimed to assess the impact of using promestriene for cervical preparation on complications in postmenopausal women undergoing surgical hysteroscopy. Methods A double-blind clinical…
Longitudinal Phospho-tau217 Predicts Amyloid Positron Emission Tomography in Asymptomatic Alzheimer’s Disease Practical Solutions and Value Highlights Value of Blood-based AD Biomarkers Blood-based AD biomarkers, such as plasma P-tau217, are increasingly used in clinical trials as a screening tool. Utility of Electrochemiluminescence Immunoassay An electrochemiluminescence (ECL) immunoassay was assessed for its ability to predict brain amyloid…
Characterizing Clinical Progression in Cognitively Unimpaired Older Individuals with Brain Amyloid: Results from the A4 Study ABSTRACT Researchers studied the sensitivity of Clinical Dementia Rating (CDR) in measuring pre-symptomatic Alzheimer’s disease progression in the A4 study. They examined specific CDR boxes and their changes over time in individuals with brain amyloid. SETTING The A4 study…
Subgroup analyses from patients with pre-treated metastatic colorectal cancer receiving trifluridine/tipiracil: results of the TALLISUR trial Key Findings Trifluridine/tipiracil (FTD/TPI) showed improved progression-free and overall survival for pre-treated metastatic colorectal cancer patients. The treatment also maintained quality of life for the patients. Study Details The TALLISUR trial in Germany assessed the efficacy, safety, and quality…
Evaluation of Staining Propensity of Silver Diamine Fluoride With and Without Potassium Iodide in Children (Project Healthy Smiles): Protocol for a Randomized Controlled Trial ABSTRACT Background: Silver diamine fluoride (SDF) is a cost-effective way to reduce sensitivity and stop cavities, but it causes black staining. Potassium iodide (KI) treatment with SDF may reduce this staining,…