Effectiveness of NIPE Index for Pain Management in Young Children Background Assessing pain in infants is difficult because they cannot express themselves verbally. Current methods rely on observing behavior, which can lead to inconsistent pain assessments. The Newborn Infant Parasympathetic Evaluation (NIPE) index uses heart rate variability for a more objective pain assessment in children…
Clinical Trial Overview Title: Comparative clinical trial of Langenlianqiao oral liquid and Lianhuaqingwen capsule in treating mild COVID-19 cases. Published in: J Health Popul Nutr. 2024 Oct 12;43(1):158. Objective The goal of this study was to assess how effective Langenlianqiao (LGLQ) oral liquid is in treating COVID-19, providing valuable information for clinical treatment. Study Design…
Effects of Probiotic and Vitamin D Co-Supplementation on Migraine Study Overview This study explores how taking probiotics and vitamin D together can help adults with migraine headaches. It focuses on improving migraine symptoms, mental health, and inflammation levels. Background Migraine headaches are a significant health issue. Current migraine medications do not work for everyone and…
Effect of Heat Stress on Fetal and Infant Growth Source: Lancet Planet Health, October 2024 Background Climate change, food insecurity, and undernutrition are major issues affecting children’s health. This study looks at how heat impacts growth from conception to age 2, which is vital for understanding child mortality and health issues. Study Methods We analyzed…
Automated Detection of Neurodevelopmental Disorders Using Mobile Technology Overview Neurodevelopmental disorders (NDs) can have complex effects on children and may persist into adulthood. Identifying these disorders early is essential for effective intervention, yet many children go undiagnosed. Digital tools, especially serious games, offer innovative ways for clinicians to detect NDs. Study Goals This study investigates…
Study Overview This research compared the effects of Estetrol (E4) combined with Drospirenone (DRSP) versus Ethinyl estradiol (EE) combined with DRSP on blood coagulation and fibrinolysis in Japanese patients with endometriosis. Key Findings – E4/DRSP combination showed significantly less impact on coagulation and fibrinolysis compared to EE/DRSP. – Major anticoagulant proteins were less reduced in…
Short-term Study Results on Arsenic Trioxide Treatment for High-risk Neuroblastoma in Children Overview A clinical study was conducted to assess the effectiveness and safety of arsenic trioxide (ATO) in combination with a modified N7 induction regimen for children with high-risk neuroblastoma (NB). Key Findings 93% of patients achieved objective remission, with a 94% disease control…
Evaluation of Low-Level Laser Therapy for Ulnar Neuropathy Overview Ulnar neuropathy at the elbow (UNE) causes pain, paresthesia, and weakness. Our study assessed the effectiveness of low-level laser therapy (LLLT) in treating UNE symptoms and improving clinical and electrophysiological outcomes. Study Design We conducted a randomized, double-blind clinical trial with 68 UNE patients aged 18-60.…
Study Protocol: Culturally Based Writing Intervention for Chinese Immigrant Breast Cancer Survivors Practical Solutions and Value This study aims to test the health benefits of expressive writing tailored for Chinese immigrant breast cancer survivors (BCSs) and explore how acculturation influences the effects of these interventions. Practical Solutions: Recruitment through community-based organizations and cancer registries Random…
Effects of Interleukin-1 Receptor Antagonism in Women with Polycystic Ovary Syndrome – the FertIL Trial Introduction Chronic low-grade inflammation in polycystic ovary syndrome (PCOS) can lead to hormonal imbalances and metabolic issues. Interleukin-1 (IL-1) is a proinflammatory cytokine that stimulates androgen production. Blocking the IL-1 pathway has shown to improve heart and metabolic health. This…
Phase 2 Trial of Anti-TL1A Monoclonal Antibody for Ulcerative Colitis Key Insights: Tulisokibart showed significant effectiveness in inducing clinical remission for patients with moderately to severely active ulcerative colitis. A genetic-based diagnostic test was used to identify patients likely to respond to treatment. Practical Solutions: Implementing genetic diagnostic tests can help identify patients who will…
Results of Four-Year Prostate Cancer Screening Study Key Findings: – MRI-targeted biopsy group had 2.8% prostate cancer detection, while systematic biopsy group had 4.5%. – Omitting biopsy in patients with negative MRI results reduced clinically insignificant cancer diagnoses by over 50%. – Risk of diagnosing incurable cancer at screening or interval was very low. Practical…
Study on Hematological Parameters in Pulmonary Tuberculosis Patients Key Takeaways: Tuberculosis (TB) management is challenging due to weakened immunity. Study focused on hematological parameters in TB patients and treatment outcomes. Results showed improvement in hemoglobin levels and decrease in white blood cell count after treatment. Practical Solutions: Utilize AI-driven platform like DocSym to consolidate clinical…
Buprenorphine: Innovative Pain Management Solution for Sickle Cell Disease Patients During Hematopoietic Stem Cell Transplant Summary Patients with sickle cell disease (SCD) undergoing bone marrow transplant (BMT) often experience severe pain uncontrolled by traditional opioids due to pre-existing tolerance. A pilot clinical trial showed that adding buprenorphine to the pain management regimen led to significantly…
Long-Term Effects of Internet-Based Cognitive Behavioral Therapy on Depression Prevention Among University Students: Randomized Controlled Factorial Trial Summary: Internet-based cognitive behavioral therapy (iCBT) has shown potential in preventing depression among university students. This study aimed to evaluate the effectiveness of different iCBT components in preventing depression. Key Findings: Over a 12-month follow-up, 10.22% of participants…
The Effects of Multifactorial Pharmacist-Led Intervention Protocol on Medication Optimisation and Adherence among Patients with Type 2 Diabetes: A Randomised Control Trial Practical Solutions and Value Highlights: Patients with chronic diseases like type 2 diabetes often struggle with medication adherence, leading to poor outcomes and increased costs. Our study tested a new pharmacist-led intervention protocol…
Practical Solutions and Value of On-Treatment Biopsies in Predicting Response to Neoadjuvant Chemotherapy for Breast Cancer Key Highlights: On-treatment biopsies provide early insight into treatment response for invasive breast cancer. Patients with complete response to chemotherapy may require less aggressive treatments. Biopsies can help adapt therapies and improve outcomes. Examining factors like tumor quantity, TILs,…
Improving Mental Health in Refugee Families Study Overview Our study aims to address mental health problems in refugee parents and prevent their impact on children through early interventions. We will provide a psychotherapeutic intervention combined with a parenting program to enhance parenting skills and support parental well-being. Study Design We will enroll 188 refugee parents…
Voice-Activated Cognitive Behavioral Therapy for Insomnia: A Randomized Clinical Trial Practical Solutions and Value Highlights: Insomnia Impact: Insomnia affects 30-50% of US breast cancer survivors. Objective: To test a voice-activated CBT-I program for improving insomnia in survivors. Participants: Breast cancer survivors with insomnia were recruited from various groups. Intervention: Participants received either a voice-interactive CBT-I…
Practical Solutions and Value Highlights Key Takeaways: – Brief stabilization psychotherapy using imagery techniques showed promising results in treating acute PTSD. – Significant reduction in PTSD, depression, anxiety, and improved quality of life observed post-treatment and at 6-month follow-up. – No exacerbation of PTSD symptoms among participants. – Safe treatment option for acute PTSD patients.…