Study Title
The effects of combining remimazolam with estazolam on postoperative hemodynamics and pain intensity in patients undergoing laparoscopic gastrointestinal surgery
Published in BMC Surgery, August 24, 2024
PMID: 39182049 | DOI: 10.1186/s12893-024-02527-8
Objective
This study aimed to investigate the effects of combining remimazolam with estazolam on hemodynamics and pain levels after laparoscopic gastrointestinal surgery.
Methods
A total of 184 patients undergoing laparoscopic gastrointestinal surgery were enrolled in a double-blind randomized controlled trial. They were divided into four groups: Study Group 1 (Remimazolam), Study Group 2 (Estazolam), Study Group 3 (Remimazolam + Estazolam), and Control Group. Hemodynamic parameters, stress responses, anxiety levels, and pain intensity were assessed at various time points.
Results
The combination of remimazolam and estazolam significantly improved hemodynamic parameters compared to the control group. Study Group 3 exhibited the lowest anxiety levels and stress responses among all groups. Furthermore, Study Group 3 had the lowest pain intensity scores at different postoperative time points.
Conclusion
The combination of remimazolam and estazolam effectively stabilized hemodynamics, reduced anxiety levels, and alleviated pain intensity after laparoscopic gastrointestinal surgery. These findings suggest that this combination therapy has the potential to improve surgical outcomes and patient comfort.
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